1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia
1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia
复制标题
DOI：
10.1016/j.neuroimage.2003.11.005
复制
发表时间：
2004-04-01
期刊：
影响因子：
5.7
通讯作者：
Alger, JR
中科院分区：
文献类型：
--
作者：
O'Neill, J;Levitt, J;Alger, JR
在成人精神分裂症患者中，磁共振成像(MRI)和磁共振波谱(MRS)显示了多个脑区的体积和代谢缺陷，其中包括前扣带回、额叶皮质、纹状体、丘脑、顶叶皮质以及额叶和顶叶白质。这项研究使用质子磁共振波谱成像(H-1MRSI)来识别儿童期精神分裂症患者这些区域潜在的代谢异常。11例儿童青少年精神分裂症患者(年龄7~18岁，男7例，女4例；除2例用药外)和20例年龄匹配的健康对照组(男10例，女10例)在1.5T和272INS回声时间获得了H-1MRSI。比较各地区组间N-乙酰化合物(NAA)、肌酸加磷酸肌酸(Cr)和胆碱化合物(Cho)的绝对水平。精神分裂症患者扣带回上前部(左右半球平均值)的肌酸值较对照组高14.3%。CHO在前扣带上叶(30.3%)、额叶皮质(13.3%)和尾状核(13.5%)较高。在丘脑中，也存在按性别诊断的交互作用，即男性患者的NAA较低，而女性受试者则不是。肌酸升高提示局部细胞能量需求异常，而Cho升高与先前提出的早发性精神分裂症患者表现出磷脂膜障碍的说法一致。NAA降低可能反映了神经元完整性的降低。(C)2004 Elsevier Inc.保留所有权利。
In adult schizophrenia, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have revealed volumetric and metabolic defects in multiple brain regions, among them the anterior cingulate, frontal cortex, striatum, thalamus, parietal cortex, and frontal and parietal white matter. This study used proton magnetic resonance spectroscopic imaging (H-1 MRSI) to identify potential metabolic abnormalities in these regions in childhood-onset schizophrenia. H-1 MRSI was acquired at 1.5 T and 272 ins echo time in 11 children and adolescents with schizophrenia (aged 7-18 years; seven boys, four girls; all but two medicated) and 20 age-matched healthy controls (10 boys, 10 girls). Absolute levels of N-acetyl compounds (NAA), creatine plus phosphocreatine (Cr), and choline compounds (Cho) were compared among groups in each region. In schizophrenic patients relative to controls, Cr was 14.3% higher in superior anterior cingulate (mean of left and right hemispheres). Cho was higher in superior anterior cingulate (30.3%), frontal cortex (13.3%), and caudate head (13.5%). In the thalamus, there was also a diagnosis-by-gender interaction, whereby NAA was lower in patients for male but not for female subjects. Elevated Cr suggests abnormal local cell-energy demand and elevated Cho is consistent with a prior proposal that patients with early age-of-onset schizophrenia exhibit phospholipid membrane disturbances. Low NAA may reflect diminished neuronal integrity. (C) 2004 Elsevier Inc. All rights reserved.