Concentrations of Cocaine and Benzoylecgonine in Femoral Blood from Cocaine-Related Deaths Compared with Venous Blood from Impaired Drivers
Concentrations of Cocaine and Benzoylecgonine in Femoral Blood from Cocaine-Related Deaths Compared with Venous Blood from Impaired Drivers
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DOI：
10.1093/jat/bkt094
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Holmgren, Anita
中科院分区：
文献类型：
--
作者：
Jones, Alan Wayne;Holmgren, Anita
检测了132例可卡因相关死亡病例的股静脉血中可卡因及其主要代谢物苯甲酰ecGonine(BZE)的浓度，并与988名被捕司机的静脉血进行了比较。采用固相萃取-同位素稀释气相色谱质谱联用法测定可卡因和BZE，定量限均为0.02 mg/L。滥用可卡因的男性(9598人)明显多于女性(25人)，尽管他们的平均年龄大致相同(2930岁)。可卡因相关死亡的平均年龄(SD)为29 7岁，与交通肇事死亡的30 8岁相比差异无统计学意义(P>0 0 5)。61例死亡病例血可卡因浓度中位数为0.1 mg/L，交通事故组为0.06 mg/L(P<0.001)。在药物中毒死亡中，可卡因浓度的中位数为0.13 mg/L(N25)，与其他死因中的0.09 mg/L(N36)无显著差异。与可卡因有关的死亡大多涉及混合药物中毒，包括共同摄入海洛因、大麻、安非他明以及苯二氮卓类和/或乙醇等合法药物。活人和死者血液中可卡因的浓度重叠，这使得仅凭分析毒理学结果预测毒性是不可行的。
The concentrations of cocaine and its major metabolite benzoylecgonine (BZE) were determined in femoral blood from 132 cocaine-related deaths and compared with venous blood from 988 apprehended drivers. Cocaine and BZE were determined by solid-phase extraction and isotope dilution gas chromatographymass spectrometry with limits of quantitation of 0.02 mg/L for both substances. Significantly more men (9598) than women (25) abused cocaine, although their mean age was about the same (2930 years). Mean age (SD) of cocaine-related deaths was 29 7 years, which was not significantly different from 30 8 years in traffic cases (P 0.05). The median concentration of cocaine in blood in 61 fatalities was 0.10 mg/L compared with 0.06 mg/L in traffic cases (P 0.001). In drug intoxication deaths, the median concentration of cocaine was 0.13 mg/L (N 25), which was not significantly different from 0.09 mg/L (N 36) in other causes of death. Cocaine-related deaths mostly involved mixed drug intoxications including co-ingestion of heroin, cannabis, amphetamines as well as legal drugs, such as benzodiazepines and/or ethanol. The concentrations of cocaine in blood from living and deceased persons overlapped, which makes it infeasible to predict toxicity from the analytical toxicology results alone.