Acute Constipation in Children Receiving Chemotherapy for Cancer
Acute Constipation in Children Receiving Chemotherapy for Cancer
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DOI：
10.1097/mph.0b013e31821a0795
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发表时间：
2011-10-01
影响因子：
1.2
通讯作者：
Pashankar, Dinesh S.
中科院分区：
文献类型：
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作者：
Pashankar, Farzana D.;Season, J. Hale;Pashankar, Dinesh S.
背景：接受癌症化疗的儿童会出现便秘，但没有关于这组儿童便秘的患病率、危险因素和严重程度的数据。方法：我们前瞻性研究了 61 名接受癌症化疗的儿童。我们对儿童和家长进行了问卷调查，并收集了有关人口统计学、化疗和化疗期间排便模式的数据。我们使用北美儿科胃肠病学、肝病学和营养学会标准来诊断便秘。家长对便秘问题的看法以及化疗期间对生活方式的影响按 0 到 3 级进行评估，其中 0 表示没有问题，1 表示轻微，2 表示严重，3 表示严重问题。 结果：35 名儿童 (57%) 在化疗期间出现持续 2 周或更长时间的急性便秘。对几个危险因素进行了分析，只有长春新碱和阿片类药物的联合使用才是便秘发生的重要危险因素。在便秘儿童中，35 名家长中有 15 名 (43%) 认为便秘是一个主要/显着问题，8 名儿童及其父母 (23%) 认为便秘对化疗期间的生活方式有主要/显着影响。结论：接受癌症化疗的儿童中有 57% 被诊断为急性便秘。长春新碱和阿片类药物的联合使用与便秘的发生有关。便秘可能是一个严重的问题，会对化疗期间的生活方式产生负面影响，需要积极的治疗。
Background: Constipation occurs in children receiving chemotherapy for cancer but there are no data about prevalence, risk factors, and severity of constipation in this group of children.Methods: We prospectively studied 61 children receiving chemotherapy for cancer. We administered questionnaires to children and parents and collected data on demographics, chemotherapy, and bowel movement pattern during chemotherapy. We used North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition criteria for the diagnosis of constipation. Parental perception of constipation as a problem and impact on lifestyle during chemotherapy were assessed on a 0 to 3 scale with 0 being no problem, 1 minor, 2 significant, and 3 being a major problem.Results: Thirty-five children (57%) had acute constipation lasting for 2 or more weeks during chemotherapy. Several risk factors were analyzed and only combined use of vincristine and opiates emerged as significant risk factor for the development of constipation. In children with constipation, 15 of 35 parents (43%) perceived constipation as a major/significant problem and 8 children and their parents (23%) perceived constipation having a major/significant impact on lifestyle during chemotherapy.Conclusions: Acute constipation was diagnosed in 57% of children receiving chemotherapy for cancer. Combined use of vincristine and opiates was associated with the development of constipation. Constipation can be a significant problem with a negative impact on lifestyle during chemotherapy and needs aggressive management.