Fatal malaria in a German couple returning from Burkina Faso
Fatal malaria in a German couple returning from Burkina Faso
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DOI：
10.1007/s15010-002-3143-5
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发表时间：
2003-08-01
期刊：
影响因子：
7.5
通讯作者：
Jelinek, T
中科院分区：
文献类型：
--
作者：
Wichmann, O;Löscher, T;Jelinek, T
我们报道一对德国夫妇从布基纳法索返回后7天被发现死在家中。尸检结果显示，两例患者的恶性疟原虫感染率约为80%。尸检时，除两例中度脾肿大和一例心肌炎外，未发现器官病理学发现。致命性疟疾的典型表现，如脑或其他器官的瘀点，或寄生虫红细胞在小静脉和毛细血管中的隔离，均不存在。缺乏隔离与过度hyperparasitemia导致全身性低氧血症和宿主细胞因子释放可能有助于这些非免疫患者的快速致命过程。
We report on a German couple found dead at home 7 days after returning from Burkina Faso. Postmortem evaluation revealed Plasmodium falciparum infection with a parasitemia of approximately 80% in both cases. No pathological findings of the organs were present at autopsy except moderate splenomegaly in both cases and myocarditis in one case. Typical findings of fatal malaria like petechial hemorrhages of the brain or other organs, or sequestration of parasitized erythrocytes in venules and capillaries were absent. Lack of sequestration with excessive hyperparasitemia leading to systemic hypoxemia and host cytokine release may have contributed to the rapid fatal course in these nonimmune patients.