Comparison of technetium-99m-ECD to Xenon-133 SPECT in normal controls and in patients with mild to moderate regional cerebral blood flow abnormalities.
Comparison of technetium-99m-ECD to Xenon-133 SPECT in normal controls and in patients with mild to moderate regional cerebral blood flow abnormalities.
复制标题
正常对照和轻度至中度局部脑血流异常患者中 technetium-99m-ECD 与 Xenon-133 SPECT 的比较。
作者：
Michael D. Devous;J. Payne;J. Lowe;R. Leroy
锝-99m-1，1-乙基半胱氨酸二聚体（ECD）被提议作为SPECT测量局部脑血流量（rCBF）的“化学微球”。然而，其分布尚未在人类中与已建立的rCBF测量进行比较。因此，我们比较了轻度至中度血流异常受试者和正常志愿者的ECD摄取和分布与133 SPECT测量的rCBF。血液和尿液化学和生命体征与ECD前值相比无变化，直至注射后7天。曲线图显示rCBF比值（133 μ g）和ECD计数密度比值之间的模式一致性。观察到rCBF比值与ECD计数密度比值的显著相关性（r = 0.77），斜率为0.64，截距为0.36。为了探讨rCBF和ECD之间的关系是否依赖于绝对流量，通过将整体CBF（133 μ l）与ECD整体计数密度相等，以ml/min/100 g为单位表示ECD感兴趣区域数据。发现这些数据的相关性比计数比数据更密切（r = 0.88）。斜率更接近1（m = 0.83），截距更接近0（B = 8.2）。此外，对于界限清楚的rCBF病变患者，在病变区域观察到ECD衍生的rCBF和133 μ rCBF之间存在显著相关性（r = 0.92）。斜率（0.80）表明ECD略微低估了病变血流。最后，从注射后1至4小时的高分辨率扫描获得的皮质灰质ROI的ECD清除缓慢（2.4%/小时）。总之，ECD是一种安全有效的局部脑灌注指标。ECD的分布与133 SPECT测量的rCBF呈线性相关，尽管我们的数据表明在正常范围的高端对血流有轻度低估。
Technetium-99m-1,1-ethyl cysteinate dimer (ECD) has been proposed as a "chemical microsphere" for SPECT measurement of regional cerebral blood flow (rCBF). However, its distribution has not yet been compared in humans to an established rCBF measure. Therefore, we compared the uptake and distribution of ECD with rCBF measured by 133Xe SPECT in subjects with mild to moderate flow abnormalities and in normal volunteers. Blood and urine chemistries and vital signs were unchanged from pre-ECD values up to seven days postinjection. Profile plots demonstrated pattern agreement between rCBF ratios (133Xe) and ECD count density ratios. A significant correlation of rCBF ratios to ECD count density ratios was observed (r = 0.77), with a slope of 0.64 and intercept of 0.36. To explore whether or not the relationship between rCBF and ECD was dependent on absolute flow, ECD region of interest data were expressed in units of ml/min/100 g by equating global CBF (133Xe) and ECD global count density. A closer correlation (r = 0.88) was found for these data than for the count ratio data. The slope was closer to one (m = 0.83) and the intercept was closer to zero (b = 8.2). Also, a significant correlation was observed between ECD-derived rCBF and 133Xe rCBF in the lesion area (r = 0.92) for patients with well-demarcated rCBF lesions. The slope (0.80) suggested a slight underestimation of lesion flow by ECD. Finally, ECD clearance from cortical gray matter ROIs derived from high-resolution scans from 1 to 4 hr postinjection was slow (2.4%/hr). In summary, ECD is a safe and effective marker of regional cerebral perfusion. The distribution of ECD is linearly related to rCBF measured by 133Xe SPECT, although our data suggest a mild underestimation of flow at the high end of the normal range.
基于 99mTc-双（氨基乙硫醇）复合物的新型脑灌注显像剂：立体异构体和生物分布。
影响因子：
7.3
作者：
Kung,HF;Guo,YZ;Yu,CC;Billings,J;Subramanyam,V;Calabrese,JC
通讯作者：
Calabrese,JC