Effects of age and hypertension status on cognition: The veterans affairs normative aging study
Effects of age and hypertension status on cognition: The veterans affairs normative aging study
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DOI：
10.1037/0894-4105.19.6.770
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发表时间：
2005-11-01
期刊：
影响因子：
2.4
通讯作者：
Gaziano, JM
中科院分区：
文献类型：
--
作者：
Brady, CB;Spiro, A;Gaziano, JM
作者在357名高血压状态稳定超过3年且无内科合并症的非痴呆、社区居住老年男性（平均年龄= 67岁）中，通过多元回归分析，研究了年龄和高血压状态（血压正常、控制、未治疗或未控制）对几项认知测试的影响。年龄是负相关的性能，但我的测试。年龄与高血压状态的语言流畅性和单词列表立即回忆：老年不受控制的高血压患者表现出显着更大的年龄递减这些测试相比，血压正常。这些发现表明，不受控制的高血压产生特定的认知功能障碍，而不仅仅是那些可归因于年龄的。这些和以前的研究结果表明，健康状况，如高血压，应定期考虑在研究“正常”认知老化。
The authors examined the influence of age and hypertensive status (normotensive, controlled, untreated, or uncontrolled) on several cognitive tests via multiple regression in 357 nondemented, community-dwelling older men (mean age = 67 years) whose hypertensive status was stable over 3 years and who had no medical comorbidities. Age was negatively associated with performance on all but I test. Age interacted with hypertensive status on verbal fluency and word list immediate recall: older uncontrolled hypertensives exhibited significantly larger age decrements on these tests compared with normotensives. These findings suggest that uncontrolled hypertension produces specific cognitive deficits beyond those attributable to age alone. These and previous findings illustrate that health conditions such as hypertension should be regularly considered in studies of "normal" cognitive aging.