Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications.
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications.
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DOI：
10.1016/j.lfs.2020.117905
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发表时间：
2020-09-01
期刊：
影响因子：
6.1
通讯作者：
Leal AR
中科院分区：
文献类型：
--
作者：
Banu N;Panikar SS;Leal LR;Leal AR
鉴于二零一九年新型冠状病毒病（COVID-19）爆发，国际科学界已联手开发有效的治疗策略。血管紧张素转换酶（ACE）2是细胞融合和吞噬SARS冠状病毒感染的必需受体。ACE 2在所有器官和系统中起着重要的生理作用。此外，ACE 2在各种急性和慢性炎症病理模型中发挥保护作用。而SARS-CoV-2刺突蛋白下调ACE 2导致血管紧张素（Ang）II/AT 1 R轴过度激活，Ang II的有害作用可以解释患者中观察到的多器官功能障碍。具体而言，下文讨论了Ang II在COVID-19中导致巨噬细胞活化综合征（MAS）和细胞因子风暴出现的作用。本文综述了血管紧张素II对血管紧张素II的毒性作用而非抑制病毒复制的治疗策略的最新研究进展。严重COVID-19患者的ACE 2下调和MAS的出现。ACE 2在器官和系统中的保护作用SARS-CoV-2下调ACE 2表达导致Ang II诱导的器官损伤。COVID-19患者出现MAS建议治疗以减少Ang II的有害作用或MAS的出现
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international scientific community has joined forces to develop effective treatment strategies. The Angiotensin-Converting Enzyme (ACE) 2, is an essential receptor for cell fusion and engulfs the SARS coronavirus infections. ACE2 plays an important physiological role, practically in all the organs and systems. Also, ACE2 exerts protective functions in various models of pathologies with acute and chronic inflammation. While ACE2 downregulation by SARS-CoV-2 spike protein leads to an overactivation of Angiotensin (Ang) II/AT1R axis and the deleterious effects of Ang II may explain the multiorgan dysfunction seen in patients. Specifically, the role of Ang II leading to the appearance of Macrophage Activation Syndrome (MAS) and the cytokine storm in COVID-19 is discussed below. In this review, we summarized the latest research progress in the strategies of treatments that mainly focus on reducing the Ang II-induced deleterious effects rather than attenuating the virus replication. ACE2 Downregulation in severe COVID-19 patient and appearance of MAS. Protective role of ACE2 in the organs and system Downregulation of ACE2 expression by SARS-CoV-2 leads to Ang II-induced organ damage. The appearance of MAS in COVID-19 patient Suggested treatment to diminish the deleterious effect of Ang II or appearance of MAS