Dendritic cells in cancer immunology.
Dendritic cells in cancer immunology.
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DOI：
10.1038/s41423-021-00741-5
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发表时间：
2022-01
影响因子：
24.1
通讯作者：
Murphy KM
中科院分区：
文献类型：
--
作者：
Murphy TL;Murphy KM
免疫检查点疗法（ICT）的临床成功在肿瘤免疫学研究中产生了爆炸性增长，因为ICT是通过免疫调节的基础研究发现的。目前的许多转化努力旨在通过鉴定与CTLA 4或PD 1/PD-L1阻断协同作用的治疗靶点来增强ICT，并且在目前公认的原则基础上得到了稳固的发展。通过持续的基础研究扩展这些原则可能有助于扩大转化工作。本着这种心态，我们将这一审查集中在与ICT基础机制直接相关的三条基础研究线索上。具体而言，这篇综述涵盖了与抗肿瘤免疫反应有关的树突状细胞（DC）生物学的三个方面，但并没有专门针对治疗用途。首先，我们回顾了DC的cDC 1亚群的发展的最新进展，确定了区分这些细胞与其他类型的DC的重要特征。其次，我们回顾了称为交叉呈递的抗原加工途径，这是在20世纪70年代中期发现的，仍然是一个谜。该途径提供了cDC 1 s特有的重要体内功能，并且可能既是生理瓶颈又是治疗靶点。最后，我们回顾了辅助细胞和DC许可的相关领域，其中CD 4 T细胞影响CD 8 T细胞反应的强度或质量。每个主题都以某种方式与ICT相关，但也是针对细胞内病原体的细胞介导免疫的基本方面。
The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in tumor immunology research because ICT was discovered through basic studies of immune regulation. Much of the current translational efforts are aimed at enhancing ICT by identifying therapeutic targets that synergize with CTLA4 or PD1/PD-L1 blockade and are solidly developed on the basis of currently accepted principles. Expanding these principles through continuous basic research may help broaden translational efforts. With this mindset, we focused this review on three threads of basic research directly relating to mechanisms underlying ICT. Specifically, this review covers three aspects of dendritic cell (DC) biology connected with antitumor immune responses but are not specifically oriented toward therapeutic use. First, we review recent advances in the development of the cDC1 subset of DCs, identifying important features distinguishing these cells from other types of DCs. Second, we review the antigen-processing pathway called cross-presentation, which was discovered in the mid-1970s and remains an enigma. This pathway serves an essential in vivo function unique to cDC1s and may be both a physiologic bottleneck and therapeutic target. Finally, we review the longstanding field of helper cells and the related area of DC licensing, in which CD4 T cells influence the strength or quality of CD8 T cell responses. Each topic is connected with ICT in some manner but is also a fundamental aspect of cell-mediated immunity directed toward intracellular pathogens.
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DOI：
10.1084/jem.20170229
发表时间：
2017-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Alloatti A;Rookhuizen DC;Joannas L;Carpier JM;Iborra S;Magalhaes JG;Yatim N;Kozik P;Sancho D;Albert ML;Amigorena S
通讯作者：
Amigorena S
影响因子：
11.4
作者：
Brass, AL;Zhu, AQ;Singh, H
通讯作者：
Singh, H
DOI：
10.4049/jimmunol.1102613
发表时间：
2012-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bajaña S;Roach K;Turner S;Paul J;Kovats S
通讯作者：
Kovats S
影响因子：
64.5
作者：
Binnewies, Mikhail;Mujal, Adriana M.;Krummel, Matthew F.
通讯作者：
Krummel, Matthew F.
桥接通道树突状细胞可诱导对输血的红细胞的免疫力。
DOI：
10.1084/jem.20151720
发表时间：
2016-05-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Calabro S;Gallman A;Gowthaman U;Liu D;Chen P;Liu J;Krishnaswamy JK;Nascimento MS;Xu L;Patel SR;Williams A;Tormey CA;Hod EA;Spitalnik SL;Zimring JC;Hendrickson JE;Stowell SR;Eisenbarth SC
通讯作者：
Eisenbarth SC