Visuomotor Coupling Shapes the Functional Development of Mouse Visual Cortex
Visuomotor Coupling Shapes the Functional Development of Mouse Visual Cortex
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DOI：
10.1016/j.cell.2017.05.023
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发表时间：
2017-06-15
期刊：
影响因子：
64.5
通讯作者：
Keller, Georg B.
中科院分区：
文献类型：
--
作者：
Attinger, Alexander;Wang, Bo;Keller, Georg B.
感觉引导行为的出现依赖于发育过程中的感觉-运动耦合。感觉运动经验如何影响神经处理尚不清楚。本研究表明，运动输出和视觉反馈之间的耦合对于小鼠初级视觉皮层（V1）第2/3层（L2/3）的视觉加工功能发展是必要的。利用虚拟现实系统，在正常和随机视运动耦合条件下饲养小鼠。我们记录了在两组小鼠中识别的兴奋性和抑制性L2/3神经元对短暂视觉运动不匹配的反应。兴奋性神经元的错配反应强烈依赖于经验，并由生长抑素阳性中间神经元介导的抑制的短暂释放驱动。这些数据与V1的L2/3计算抑制性视觉输入和兴奋性运动相关输入之间的差异的模型一致，其中这两种输入之间的平衡被视觉运动经验精细地调节。
The emergence of sensory-guided behavior depends on sensorimotor coupling during development. How sensorimotor experience shapes neural processing is unclear. Here, we show that the coupling between motor output and visual feedback is necessary for the functional development of visual processing in layer 2/3 (L2/3) of primary visual cortex (V1) of the mouse. Using a virtual reality system, we reared mice in conditions of normal or random visuomotor coupling. We recorded the activity of identified excitatory and inhibitory L2/3 neurons in response to transient visuomotor mismatches in both groups of mice. Mismatch responses in excitatory neurons were strongly experience dependent and driven by a transient release from inhibition mediated by somatostatin-positive interneurons. These data are consistent with a model in which L2/3 of V1 computes a difference between an inhibitory visual input and an excitatory locomotion-related input, where the balance between these two inputs is finely tuned by visuomotor experience.