The dynamic characteristics of the mouse horizontal vestibule-ocular and optokinetic response
The dynamic characteristics of the mouse horizontal vestibule-ocular and optokinetic response
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DOI：
10.1016/s0006-8993(00)03180-2
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发表时间：
2001-02-02
期刊：
影响因子：
2.9
通讯作者：
De Zeeuw, DI
中科院分区：
文献类型：
--
作者：
van Alphen, AM;Stahl, JS;De Zeeuw, DI
在本研究中，视动反射，前庭眼反射和它们的相互作用进行了研究，在小鼠，使用改进的结膜下搜索线圈技术。对于低于8度/秒的峰值速度，对正弦视动刺激的眼反应的增益相对恒定，范围为0.7至0.8。对于更快的刺激，增益与速度成比例地降低。前庭眼反射的作用是对正弦刺激产生正弦补偿性眼球运动。随着刺激频率的降低，眼球运动相对于头部运动的相位提前，这是半规管扭转摆行为的熟悉特征。前庭眼反射的一阶时间常数，从前庭速度阶跃后的眼速度衰减测量，是660毫秒。前庭眼反射的响应随刺激振幅而变化，具有较高的增益和较小的相位导致时，刺激振幅增加。作为这种非线性行为的结果，反射增益与0.1-1.6 Hz频率范围内的刺激加速度密切相关。当在光中进行全身旋转时，视动和前庭系统组合以在0.1-1.6 Hz的测试频率范围内产生几乎恒定的响应增益（约0.8）和相位（约0度）。我们的结论是，小鼠的补偿性眼球运动与其他哺乳动物的补偿性眼球运动相似，但也存在显着差异，即角VOR的表观时间常数较短，非线性较强。(C)2001 Elsevier Science B. V.保留所有权利。
In the present study the optokinetic reflex, vestibulo-ocular reflex and their interaction were investigated in the mouse, using a modified subconjunctival search coil technique. Gain of the ocular response to sinusoidal optokinetic stimulation was relatively constant for peak velocities lower than 8 degrees /s, ranging from 0.7 to 0.8. Gain decreased proportionally to velocity for faster stimuli. The vestibule-ocular reflex acted to produce a sinusoidal compensatory eye movement in response to sinusoidal stimuli. The phase of the eye movement with respect to head movement advanced as stimulus frequency decreased, the familiar signature of the torsion pendulum behavior of the semicircular canals. The first-order time constant of the vestibule-ocular reflex, as measured from the eye velocity decay after a vestibular velocity step, was 660 ms. The response of the vestibule-ocular reflex changed with stimulus amplitude, having a higher gain and smaller phase lead when stimulus amplitude was increased. As a result of this nonlinear behavior, reflex gain correlated strongly with stimulus acceleration over the 0.1-1.6 Hz frequency range. When whole body rotation was performed in the light the optokinetic and vestibular system combined to generate nearly constant response gain (approximately 0.8) and phase (approximately 0 degrees) over the tested frequency range of 0.1-1.6 Hz. We conclude that the compensatory eye movements of the mouse are similar to those found in other afoveate mammals, but there are also significant differences, namely shorter apparent time constants of the angular VOR and stronger nonlinearities. (C) 2001 Elsevier Science B.V. All rights reserved.