Altitude-induced changes in muscle contractile properties.
Altitude-induced changes in muscle contractile properties.
复制标题
海拔引起的肌肉收缩特性的变化。
DOI：
--
复制
发表时间：
2009
影响因子：
2.1
通讯作者：
T. Rupp
中科院分区：
文献类型：
--
作者：
S. Perrey;T. Rupp
由于其高能量需求，骨骼肌对氧分压的变化敏感。大多数人体研究在体内骨骼肌功能在缺氧进行自愿收缩。然而，骨骼肌功能的特征不仅在于自主最大或重复力产生能力，而且在于诱发的肌肉收缩产生的力（即，力-频率特性）。这篇简短的综述报道了急性或长期暴露于缺氧对人体骨骼肌性能和收缩特性的影响。后者取决于收缩蛋白的数量和类型以及兴奋-收缩偶联的细胞机制的效率。对人类的观察表明，缺氧（在模拟上升或短暂暴露期间）对随意收缩期间肌肉动作电位的膜传播产生适度影响。总的来说，在人类的生理条件下，包括登山。在珠峰上，最大的力量产生能力几乎没有变化。有趣的是，似乎对慢性缺氧的适应使对骨骼肌功能障碍的影响最小化（即，抗疲劳运动期间和肌肉收缩特性的损害），这可能会在某些单独肌肉运动的急性缺氧期间发生。只有超过一定强度（30%MVC）并导致实质性和持续性缺血的持续等长运动才不受急性缺氧的影响。
Because of its high energetic demand, skeletal muscle is sensitive to changes in the partial pressure of oxygen. Most human studies on in vivo skeletal muscle function during hypoxia were performed with voluntary contractions. However, skeletal muscle function is not only characterized by voluntary maximal or repeated force- generating capacity, but also by force generated by evoked muscle contractions (i.e., force-frequency properties). This mini-review reports on the effects of acute or prolonged exposure to hypoxia on human skeletal muscle performance and contractile properties. The latter depend on both the amount and type of contractile proteins and the efficiency of the cellular mechanism of excitation-contraction coupling. Observations on humans indicate that hypoxia (during simulated ascent or brief exposure) exerts modest influences on the membrane propagation of the muscle action potentials during voluntary contractions. Overall in humans, in physiological conditions, including that of climbing Mt. Everest, there is extraordinarily little that changes with regard to maximal force-generating capacity. Interestingly, it appears that the adaptations to chronic hypoxia minimize the effects on skeletal muscle dysfunction (i.e., impairment during fatigue resistance exercise and in muscle contractile properties) that may occur during acute hypoxia for some isolated muscle exercises. Only sustained isometric exercise exceeding a certain intensity (30% MVC) and causing substantial and sustained ischemia is not affected by acute hypoxia.
超氧化物清除剂增强大鼠膈肌对缺氧的收缩反应，但不增强能量反应。
DOI：
10.1152/japplphysiol.01022.2004
发表时间：
2005
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Wright,VP;Klawitter,PF;Iscru,DF;Merola,AJ;Clanton,TL
通讯作者：
Clanton,TL
影响因子：
3.3
作者：
Mohanraj, P;Merola, AJ;Clanton, TL
通讯作者：
Clanton, TL