Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering
Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering
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DOI：
10.1098/rstb.2007.2115
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发表时间：
2007-08-29
影响因子：
6.3
通讯作者：
Koide, Takaki
中科院分区：
文献类型：
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作者：
Koide, Takaki
胶原蛋白具有独特的三螺旋结构，是所有多细胞动物细胞外基质（ECM）的主要成分。胶原蛋白不仅维持组织和器官的结构完整性，而且还调节许多生物学事件，包括细胞附着、迁移和分化、组织再生和动物发育。胶原蛋白的特异性功能通常由胶原蛋白结合分子（膜受体、可溶性因子和其他ECM组分）与胶原蛋白三螺旋上显示的某些结构的特异性相互作用触发。因此，模拟天然胶原结构的合成三螺旋肽已被用于研究单个胶原-蛋白相互作用以及胶原结构和稳定性。本文的第一部分阐述了各种胶原模拟肽的设计及其在基质生物学中的应用。胶原蛋白也被认为是再生医学和组织工程中最有前途的生物材料之一。然而，在人体中使用动物源性胶原蛋白可能会使受体面临病原体传播或过敏反应的风险。因此，安全的人工胶原替代物的生产目前是相当大的兴趣。本文的后半部分综述了近年来人工胶原作为新型生物材料的研究进展。
Collagens, characterized by a unique triple-helical structure, are the predominant component of extracellular matrices (ECMs) existing in all multicellular animals. Collagens not only maintain structural integrity of tissues and organs, but also regulate a number of biological events, including cell attachment, migration and differentiation, tissue regeneration and animal development. The specific functions of collagens are generally triggered by specific interactions of collagen-binding molecules (membrane receptors, soluble factors and other ECM components) with certain structures displayed on the collagen triple helices. Thus, synthetic triple-helical peptides that mimic the structure of native collagens have been used to investigate the individual collagen-protein interactions, as well as collagen structure and stability. The first part of this article illustrates the design of various collagen-mimetic peptides and their recent applications in matrix biology. Collagen is also acknowledged as one of the most promising biornaterials in regenerative medicine and tissue engineering. However, the use of animal-derived collagens in human could put the recipients at risks of pathogen transmission or allergic reactions. Hence, the production of safe artificial collagen surrogates is currently of considerable interest. The latter part of this article reviews recent attempts to develop artificial collagens as novel biomaterials.