Evidence for the involvement of the pallidum in the modulation of seizures in a genetic model of absence epilepsy in the rat
Evidence for the involvement of the pallidum in the modulation of seizures in a genetic model of absence epilepsy in the rat
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DOI：
10.1016/s0304-3940(99)00113-5
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发表时间：
1999-04-16
影响因子：
2.5
通讯作者：
Depaulis, A
中科院分区：
文献类型：
--
作者：
Deransart, C;Riban, V;Depaulis, A
在不同的癫痫动物模型中，抑制丘脑底核（subthalamic nucleus，简称ENA）可以抑制癫痫发作。本研究的目的是在大鼠遗传模型中研究苍白球对海马的输入在控制失神发作中的作用。通过局部注射GABA（A）拮抗剂解除苍白球或腹侧苍白球的抑制，可抑制失神发作。相反，GABA（A）激动剂对腹侧苍白球的抑制加重了失神发作。此外，苍白球内注射GABA（A）拮抗剂的抗癫痫作用与黑质细胞外谷氨酸水平的降低相关。我们的研究结果表明，苍白球和腹侧苍白球对失神发作产生调节作用，并表明这些作用是通过丘脑介导的。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Inhibition of the subthalamic nucleus (STN) has been shown to suppress seizures in different animal models of epilepsy. The aim of this study was to examine the role of the pallidal inputs to the STN in the control of absence seizures in a genetic model in the rat. Disinhibition of the globus pallidus or the ventral pallidum, by local injections of a GABA(A) antagonist, suppressed absence seizures. Conversely, inhibition of the ventral pallidum by a GABA(A) agonist aggravated absence seizures. Furthermore, the antiepileptic effects of intrapallidal injections of a GABA(A) antagonist were correlated with a decrease of extracellular levels of glutamate in the substantia nigra. Our results show that both the globus pallidus and the ventral pallidum exert a modulatory influence on absence seizures and suggest that these effects are mediated through the STN. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.