Sentinel lymph node biopsy and aberrant lymphatic drainage in recurrent breast cancer: Findings likely to change treatment decisions
Sentinel lymph node biopsy and aberrant lymphatic drainage in recurrent breast cancer: Findings likely to change treatment decisions
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DOI：
10.1002/jso.24423
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发表时间：
2016-12-01
影响因子：
2.5
通讯作者：
Gulluoglu, Bahadir M.
中科院分区：
文献类型：
--
作者：
Karanlik, Hasan;Ozgur, Ilker;Gulluoglu, Bahadir M.
背景和目的前哨淋巴结活检（SLNB）是否适用于第二次乳腺癌或乳腺癌复发患者尚不清楚。本研究的目的是评估SLNB程序在复发性乳腺癌患者的可行性。MethodsPatients with non-metastatic复发性N 0乳腺癌在同侧乳腺被列入。患者根据其初次乳房、腋窝和整体手术进行分组。评估引流的存在及其模式以及SLNB成功率和总体腋窝受累率。结果75例患者中，平均年龄为52.5岁，无病期为82（9-312）个月。42例（56%）患者淋巴引流成功。既往接受SLNB治疗的患者引流阳性率（82.6%）高于接受腋窝淋巴结清扫术（ALND）的患者（44.2%; P= 0.002）。引流阳性患者中64.3%存在异常淋巴引流。SLNB再次手术成功率为92.9%。12例（16%）患者改变了辅助治疗计划。在15例患者中，阴性SLNB防止腋窝dismutation.ConclusionsReoperative SLNB似乎是技术上可行的N 0复发性乳腺癌患者。它可以进一步避免不必要的ALND和导致辅助治疗计划的变化。《肿瘤外科杂志》2016;114：796-802. (c)2016 Wiley Periodicals，Inc.
Background and ObjectivesIt is not clear whether sentinel lymph node biopsy (SLNB) can be applied to patients with a second breast cancer or recurrence occurring at previously treated breast. The purpose of this study was to assess the feasibility of SLNB procedure in patients with recurrent breast cancer.MethodsPatients with non-metastatic recurrent N0 breast cancer at ipsilateral breast were included. Patients were grouped according to their initial breast, axilla, and overall surgery. Presence of drainage and its pattern as well as SLNB success rate and overall axillary involvement rates were assessed. Findings were compared.ResultsOut of 75 patients, mean age was 52.5 years and disease-free interval was 82 (9-312) months. Lymphatic drainage was successful in 42 (56%) patients. Drainage positivity was more frequent in patients who were previously treated with SLNB (82.6%) than in patients who underwent axillary lymph node dissection (ALND) (44.2%; P=0,002). Aberrant lymphatic drainage was detected in 64.3% of drainage positive patients. Success rate of reoperative SLNB was 92.9%. Adjuvant treatment plan was altered in 12 (16%) patients. In 15 patients, negative SLNB prevented axillary dissection.ConclusionsReoperative SLNB seems to be technically feasible in N0 recurrent breast cancer patients. It may further avoid unnecessary ALND and lead changes in adjuvant treatment plans. J. Surg. Oncol. 2016;114:796-802. (c) 2016 2016 Wiley Periodicals, Inc.