REGULATION OF ION CHANNELS BY SECRETED KLOTHO
REGULATION OF ION CHANNELS BY SECRETED KLOTHO
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DOI：
10.1007/978-1-4614-0887-1_7
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Huang, Chou-Long
中科院分区：
文献类型：
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作者：
Huang, Chou-Long
Klotho是一种抗衰老蛋白，主要在肾脏、甲状旁腺和脑脉络丛中表达。Klotho以两种形式存在，膜形式和可溶性分泌形式。最近的研究表明，分泌Klotho具有唾液酸酶活性，并通过该活性调节多种离子通道。通过分泌的Klotho从上皮Ca 2+通道TRPV 5和肾K+通道ROMK的N-聚糖链去除末端唾液酸暴露了潜在的二糖半乳糖-N-乙酰葡糖胺，半乳糖凝集素-1的配体。在细胞外表面与半乳糖凝集素-1结合阻止内化并导致通道在质膜上的积累。未来的研究将调查分泌Klotho是否通过相同的机制调节其他膜糖蛋白的细胞表面表达。
Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands and choroid plexus of the brain. Klotho exists in two forms, a membrane form and a soluble secreted form. Recent studies show that the secreted Klotho possess sialidase activity and regulates several ion channels via the activity. Removal of terminal sialic acids from N-glycan chains of the epithelial Ca2+ channel TRPV5 and the renal K+ channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N-acetylglucosamine, a ligand for galectin-1. Binding to galectin-1 at the extracellular surface prevents internalization and leads to accumulation of the channels on the plasma membrane. Future studies will investigate whether secreted Klotho regulates cell-surface expression of other membrane glycoproteins via the same mechanism.