The role of the rostral frontal cortex (area 10) in prospective memory: a lateral versus medial dissociation
The role of the rostral frontal cortex (area 10) in prospective memory: a lateral versus medial dissociation
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DOI：
10.1016/s0028-3932(02)00327-5
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
Frith, CD
中科院分区：
文献类型：
--
作者：
Burgess, PW;Scott, SK;Frith, CD
使用（H2O）-O-15 PET方法，我们研究了额叶极侧和上级吻侧的局部脑血流（rCBF）变化的先前发现是否（主要是布罗德曼区（BA）10）在前瞻记忆（PM）范式（即涉及在延迟后采取预定行动的行为）可以仅仅归因于这些任务比通常使用的基线条件更困难。在四种条件下管理三种不同的任务：基线简单RT;仅注意力要求的持续任务;持续任务加上延迟意图（未练习）;持续任务加上延迟意图（练习）。在前瞻性记忆条件下，我们发现显着的rCBF下降，在上级内侧方面的吻侧前额叶皮层（BA 10）相对于基线或正在进行的任务只有条件。然而，更多的横向方面的10区（加上中背侧丘脑）表现出相反的模式，与rCBF增加的前瞻性记忆条件相对于其他条件。这些模式在所有三项任务中广泛复制。由于内侧和外侧吻侧区域均显示：（a）在更用力的条件下rCBF较低的情况（如通过增加的RT和错误率估计的）比在不太费力的情况下;和（B）在这些区域中rCBF和RT持续时间或错误数量之间没有相关性，在前瞻性记忆任务期间额叶的嘴侧方面的rCBF变化的简单任务难度解释被拒绝。相反，赞成的解释集中在这些情况下，无论使用的确切刺激或意图的确切性质所提出的特定处理要求。此外，结果表明内侧和外侧喙前额叶皮层的不同作用，前者参与抑制内部产生的思想，后者维持它。（C）2003年爱思唯尔科学有限公司版权所有。
Using the (H2O)-O-15 PET method, we investigated whether previous findings of regional cerebral blood flow (rCBF) changes in the polar and superior rostral aspects of the frontal lobes (principally Brodmann's area (BA) 10) during prospective memory (PM) paradigms (i.e. those involving carrying out an intended action after a delay) can be attributed merely to the greater difficulty of such tasks over the baseline conditions typically employed. Three different tasks were administered under four conditions: baseline simple RT; attention-demanding ongoing task only; ongoing task plus a delayed intention (unpracticed); ongoing task plus delayed intention (practiced). Under prospective memory conditions, we found significant rCBF decreases in the superior medial aspects of the rostral prefrontal cortex (BA 10) relative to the baseline or ongoing task only conditions. However more lateral aspects of area 10 (plus the medio-dorsal thalamus) showed the opposite pattern, with rCBF increases in the prospective memory conditions relative to the other conditions. These patterns were broadly replicated over all three tasks. Since both the medial and lateral rostral regions showed: (a) instances where rCBF was lower during a more effortful condition (as estimated by increased RTs and error rates) than in a less effortful one; and (b) there was no correlation between rCBF and RT durations or number of errors in these regions, a simple task difficulty explanation of the rCBF changes in the rostral aspects of the frontal lobes during prospective memory tasks is rejected. Instead, the favoured explanation concentrates upon the particular processing demands made by these situations irrespective of the precise stimuli used or the exact nature of the intention. Moreover, the results suggest different roles for medial and lateral rostral prefrontal cortex, with the former involved in suppressing internally-generated thought, and the latter in maintaining it. (C) 2003 Elsevier Science Ltd. All rights reserved.