New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum
New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum
复制标题
DOI：
10.1021/np000401s
复制
发表时间：
2001-04-01
影响因子：
5.1
通讯作者：
Gräfe, U
中科院分区：
文献类型：
--
作者：
Jadulco, R;Proksch, P;Gräfe, U
从海绵Callysongia aerizusa中分离的Cladosporium herbarum的有机提取物的生物测定指导分馏产生了两种新的大环内酯代谢物：pandangelin 3和4（1和2）以及已知的真菌代谢物pandangelin 2（3）、cladosporium B（4）和iso-cladosporium B（5）。还分离出具有抗微生物活性（抗枯草芽孢杆菌和金黄色葡萄球菌）的呋喃羧酸：Sumiki酸（6）及其新衍生物乙酰Sumiki酸（7）。所有化合物的结构均经波谱方法鉴定。
Bioassay-guided fractionation of organic extracts of Cladosporium herbarum, isolated from the marine sponge Callyspongia aerizusa, yielded two new macrolide metabolites: pandangolide 3 and 4 (1 and 2) and the known fungal metabolites pandangolide 2 (3), cladospolide B (4), and iso-cladospolide B (5). Also isolated were the antimicrobially active (against Bacillus subtilis and Staphylococcus aureus) furan carboxylic acids: Sumiki's acid (6) and its new derivative, acetyl Sumiki's acid (7). All structures were elucidated by spectroscopic methods.