Chronic transvascular fluid flux and lymph flow during volume-loading hypertension.
Chronic transvascular fluid flux and lymph flow during volume-loading hypertension.
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容量负荷性高血压期间的慢性经血管液体流动和淋巴流动。
DOI：
10.1152/ajpheart.1990.258.5.h1524
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
ManningJr,RD
中科院分区：
文献类型：
--
作者：
Valenzuela-Rendon,J;ManningJr,RD
在5只清醒犬上，观察了容量负荷性高血压时毛细血管流量和淋巴流量在细胞外液容量分布中的慢性作用。同样，对血浆蛋白在微血管系统中的分布进行了评估。在容量负荷性高血压的早期，液体平衡为正，导致细胞外液和血浆容量分别增加25%和15%。胸导管淋巴流量增加了一倍多，但跨毛细血管液体流量的增加更大。因此，间质液体体积增加了30%。这种从血管系统到间质的液体转移可能阻止了动脉压的进一步上升。此外，跨毛细血管的蛋白质流量增加了一倍多，但随之而来的淋巴蛋白质转运的增加阻止了血浆蛋白质质量的任何变化。在盐水输注期的后期，淋巴流量向对照方向下降，导致液体净转移到间质中。综上所述，毛细血管内液体流量和淋巴流量在细胞外液容量分布中起重要作用。
The chronic roles of the transcapillary fluid flux and lymph flow in the distribution of extracellular fluid volume during volume-loading hypertension were investigated in five conscious dogs. Similarly, the distribution of plasma proteins across the microvasculature was evaluated. During the early phases of volume-loading hypertension the fluid balance was positive, which caused the extracellular fluid volume and the plasma volume to increase 25 and 15%, respectively. The thoracic duct lymph flow more than doubled, but the increase in transcapillary fluid flux was even greater. Therefore the interstitial fluid volume increased 30%. This fluid shift from the vasculature into the interstitium probably prevented an even greater rise in arterial pressure. In addition, the transcapillary protein flux more than doubled, but the accompanying increase in lymph protein transport prevented any change in plasma protein mass. During the latter part of the saline-infusion period, the lymph flow declined toward its control, which caused a net transfer of fluid into the interstitium. In conclusion, the transcapillary fluid flux and lymph flow play significant roles in extracellular fluid volume distribution.