On the use of caffeine as a contrast booster for BOLD fMRI studies
On the use of caffeine as a contrast booster for BOLD fMRI studies
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DOI：
10.1006/nimg.2001.0973
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发表时间：
2002-01-01
期刊：
影响因子：
5.7
通讯作者：
Parrish, TB
中科院分区：
文献类型：
--
作者：
Mulderink, TA;Gitelman, DR;Parrish, TB
本研究探讨了咖啡因作为一种试剂，以改善功能磁共振成像（fMRI）的BOLD（血氧水平依赖）信号反应的可能性。先前的研究已经证明，咖啡因有能力重置血流和神经元活动之间的耦合水平。在目前的研究中，已经表明，咖啡因会导致脑灌注减少多达13.2%，而不会改变性能。咖啡因是一种脑血管收缩剂，可导致脱氧血红蛋白浓度增加，从而使BOLD基线静息信号降低4.4%。在激活期间，血管系统从低于正常基线水平响应，血流量和血容量正常增加，导致BOLD对比度总体增加。在视觉提示运动任务的执行过程中，这种增加可以高达22-37%。BOLD对比度如此大幅度的增加，可以用来改善图像分辨率、采集方案或功能磁共振成像实验的任务设计。咖啡因有可能被用作功能磁共振成像实验的对比增强剂。(C)2002年，Elsevier Science。
This study explored the possible use of caffeine as an agent to improve the BOLD (blood oxygen level-dependent) signal response in fMRI. Previous research has demonstrated that caffeine has the ability to reset the level of coupling between blood flow and neuronal activity. In the present study, it has been shown that caffeine causes a decrease in cerebral perfusion by as much as 13.2% without a change in performance. Caffeine is a cerebral vasoconstrictor that causes an increase in the concentration of deoxyhemoglobin and thus a decrease in the BOLD baseline resting signal by 4.4%. During activation, the vasculature responds from below-normal baseline levels with a normal increase in blood flow and volume, resulting in an overall increase in the BOLD contrast. This increase can be as large as 22-37% during the performance of a visually cued motor task. The benefit of such a large increase in the BOLD contrast could be used to improve the image resolution, the acquisition scheme, or the task design of fMRI experiments. Caffeine has the potential to be used as a contrast booster for fMRI experiments. (C) 2002 Elsevier Science.