Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro.
Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro.
复制标题
白血病抑制因子可以增强体外小鼠巨核细胞的产生。
DOI：
10.1182/blood.v77.10.2150.bloodjournal77102150
复制
发表时间：
1991
期刊：
影响因子：
20.3
通讯作者：
N. Nicola
中科院分区：
文献类型：
--
作者：
D. Metcalf;D. Hilton;N. Nicola
小鼠白血病抑制因子（LIF）的受体在未成熟和成熟的小鼠巨核细胞上被证明。LIF单独对正常小鼠巨核细胞或其前体细胞的存活或增殖没有影响。然而，LIF与多能集落刺激因子（Multi-CSF）（白细胞介素-3）的组合增强了能够被Multi-CSF刺激的巨核细胞集落形成;增强涉及所有类型的巨核细胞集落，并导致形成数量增加的巨核细胞。这些观察结果为以下观察结果提供了可能的基础：当体内注射LIF时，观察到巨核细胞数量和血小板水平升高。
Receptors for murine leukemia inhibitory factor (LIF) were demonstrated on immature and mature murine megakaryocytes. LIF alone had no effects in culture on the survival or proliferation of normal murine megakaryocytes or their precursors. However, combination of LIF with multipotential-colony-stimulating factor (Multi-CSF) (interleukin-3) enhanced the megakaryocyte colony formation able to be stimulated by Multi-CSF; the enhancement involved all types of megakaryocyte colony and resulted in the formation of increased numbers of megakaryocytes. These observations provide a possible basis for the observation that, when LIF is injected in vivo, elevations are observed in megakaryocyte numbers and platelet levels.
小鼠白血病抑制因子对白血病和正常小鼠造血细胞作用的克隆分析。
影响因子：
11.4
作者：
Metcalf,D;Hilton,DJ;Nicola,NA
通讯作者：
Nicola,NA