Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder
Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder
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DOI：
10.1097/00001756-200403220-00025
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发表时间：
2004-03-22
期刊：
影响因子：
1.7
通讯作者：
Leboyer, M
中科院分区：
文献类型：
--
作者：
Delorme, R;Krebs, MO;Leboyer, M
一些证据表明，强迫症（OCD）可能是神经元功能障碍的后果。我们对156例患者和141例对照进行了病例对照研究，并对124例亲子三人组进行了传递不平衡检验，以寻找强迫症与两种红藻氨酸受体GRIK2和GRIK3之间的关联。使用GRIK2中的三个单核苷酸多态性（SNP）和GRIK3中的一个，我们在病例对照或基于家庭的分析中没有发现关联的证据。只有GRIK2 SNP 1867，最近与自闭症有关，比预期的传播少（p
Several lines of evidence suggest that obsessive compulsive disorder (OCD) could be the consequence of glutamatergic dysfunction. We performed a case-control study in 156 patients and 141 controls and the transmission disequilibrium test in 124 parent-offspring trios to search for association between OCD and two kainate receptors, GRIK2 and GRIK3. Using three single nucleotide polymorphisms (SNP) in GRIK2 and one in GRIK3, we found no evidence for association in case-control or family-based analyses. Only the GRIK2 SNP 1867, recently associated with autism, was less transmitted than expected (p