Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus
Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus
复制标题
DOI：
10.3969/j.issn.1673-5374.2012.03.007
复制
发表时间：
2012-01-01
影响因子：
6.1
通讯作者：
Xue, Jingfeng
中科院分区：
文献类型：
--
作者：
Chen, Zhihong;He, Yaqiang;Xue, Jingfeng
本研究采用连续腹腔注射链脲佐菌素的方法建立大鼠2型糖尿病模型。丝胶灌胃35d后，大鼠血糖水平明显下降，海马神经元凋亡减少，Akt蛋白磷酸化和核转录因子kappaB表达增强，而Bclxl/Bcl2相关死亡启动子表达降低。结果表明，丝胶可通过调节Akt信号转导通路的异常改变来减少糖尿病大鼠海马神经细胞的凋亡。
In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.