Thyroid cancer after diagnostic doses of iodine-131: a retrospective cohort study.
Thyroid cancer after diagnostic doses of iodine-131: a retrospective cohort study.
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诊断剂量的碘 131 后的甲状腺癌：一项回顾性队列研究。
DOI：
10.1093/jnci/80.14.1132
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Lindberg,RS
中科院分区：
文献类型：
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作者：
Holm,LE;Wiklund,KE;Lundell,GE;Bergman,NA;Bjelkengren,G;Cederquist,ES;Ericsson,UB;Larsson,LG;Lidberg,ME;Lindberg,RS
在1951年至1969年期间，对35074例疑似甲状腺疾病患者的甲状腺癌发病率进行了评估，平均为1.92兆贝克勒尔(MBq) μCi为131i。甲状腺的辐射剂量平均约为0.5戈瑞。检查时平均年龄44岁；5%低于。与瑞典癌症登记处的记录联系（131）相比，根据一般人群率（标准化发病率(SIR)=1.27,95%可信区间=0.94‐1.67），预期为39.4。男性患者的风险最高（SIR=2.22,(i)n=23），而接受超过74或2.74 MBq ofI的患者（SIR=2.04,(i)n=17）。然而，这些观察到的疑似甲状腺肿瘤接受了最高的暴露和最高的总体风险（SIR=2.77, (i)n=34）。除疑似肿瘤外，其他原因给予131i的患者风险没有增加（SIR=0.62, (i)n=16）。预期处于最高风险的患者，即女性（SIR=1.12, (i)n=40）和观察10年或更长时间的患者（SIR=0.93, (i)n=27），没有显示剂量反应的证据。总的来说，这些数据几乎不能证明内部β颗粒的致癌潜力可能低至外部x射线或γ射线的四分之一。[J] contemporary medicine; 2009；80:1132 - 1138]
The incidence of thyroid cancer was evaluated in 35,074 patients examined for suspected thyroid disorders between 1951 and 1969 with an average of 1.92 megabecquerel [(MBq) μCi] of131I. The radiation dose to the thyroid gland was, on the average, approximately 0.5 Gy. The mean age at the time of examination was 44 years; 5% were under. Record linkage with the Swedish cancer Register identified131Iexamination, in contrast to 39.4 expected based on general population rates [standardized incidence ratio (SIR)=1.27,95% confidence interval=0.94‐1.67]. Risk was highest among males (SIR=2.22,(i)n=23), and patients receiving more than 74 ⊸ or 2.74 MBq ofI(SIR=2.04,(i)n=17). However, these observations were suspected thyroid tumor received the highest131Iexposures and were at highest overall risk (SIR=2.77, (i)n=34). Patients given131Ifor reasons other than a suspected tumore were not at increased risk (SIR=0.62, (i)n=16). Patients anticipated to be at highest risk, i.e., women (SIR=1.12, (i)n=40) and those observed for 10 years or more (SIR=0.93, (i)n=27), showed no evidence of a dose response. Overall, these data provide little proof that131Iis carcinogenic potential of internal131Ibeta particles might be as low as four times less than external x rays or γ rays. [J Natl Cancer Inst 1988;80:1132-1138]