The hormonal control of sexual development.
The hormonal control of sexual development.
复制标题
性发育的荷尔蒙控制。
DOI：
10.1126/science.7010602
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Griffin,JE
中科院分区：
文献类型：
--
作者：
Wilson,JD;George,FW;Griffin,JE
男性和女性人类胚胎在妊娠的第一阶段发育相同。不同的性腺随后分化为卵巢或睾丸，并很快开始分泌它们特有的激素。如果卵巢（或无性腺）存在，则最终表型为雌性；因此，在胚胎发生过程中，雌性发育不需要性腺激素。胎儿睾丸的两种激素——<s:1>勒氏回归激素和睾酮——负责雄性表型的形成。对单基因缺陷性发育异常患者皮肤成纤维细胞的分析表明，睾酮负责男性内生殖道的阳刚之气，其衍生物双氢睾酮导致男性外生殖器的发育，并且这两种激素在胚胎中通过相同的受体机制在出生后的生活中起作用。
Male and female human embryos develop identically during the first phase of gestation. The indifferent gonads then differentiate into ovaries or testes and soon begin to secrete their characteristic hormones. If ovaries (or no gonads) are present the final phenotype is female; thus no gonadal hormones are required for female development during embryogenesis. Two hormones of the fetal testis—Müllerian regression hormone and testosterone—are responsible for the formation of the male phenotype. Analysis of fibroblasts from the skin of patients with abnormalities of sexual development due to single gene defects shows that testosterone is responsible for virilization of the male internal genital tract, that its derivative dihydrotestosterone causes development of the male external genitalia, and that both hormones act in the embryo by the same receptor mechanisms operative in postnatal life.