Parceling Human Accumbens into Putative Core and Shell Dissociates Encoding of Values for Reward and Pain
Parceling Human Accumbens into Putative Core and Shell Dissociates Encoding of Values for Reward and Pain
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DOI：
10.1523/jneurosci.1731-13.2013
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发表时间：
2013-10-09
影响因子：
5.3
通讯作者：
Apkarian, A. Vania
中科院分区：
文献类型：
--
作者：
Baliki, Marwan N.;Mansour, Ali;Apkarian, A. Vania
除了在发出奖励结果和奖励预测线索以及调节积极强化方面已确立的作用外，越来越多的证据表明，伏隔核 (NAc) 神经元还发出厌恶事件和预测这些事件的线索。在这里，我们使用扩散纤维束成像将人类的右侧 NAc 细分为外侧嘴侧（假定的核心，pcore）和内侧尾侧（假定的壳，pshell）细分。基于概率纤维束描记术，这两个子区域表现出与前额皮质和皮质下边缘区域的差异结构连通性。我们还展示了金钱奖励和热痛感知任务的两个细分中的每一个的独特作用：pshell 发出即将到来的疼痛信号和金钱赌博的价值预测，以及 pcore 激活预期热痛停止（发出镇痛奖励值的信号）。我们检查了静息状态、金钱奖励和热痛任务的功能连接，并且在所有三种条件下观察到，右 NAc 的 pcore 和 pshell 与右半球内的前额皮质和皮质下边缘目标表现出不同的同步模式（功能连接）。为了验证 NAc 分离，我们将右侧 NAc pcore 和 pshell 的坐标镜像到左半球，并检查左半球的结构和静息状态连接性。后一种分析密切复制了我们获得的右半球的特定目标连接。总体而言，我们证明人类 NAc 可以根据结构和功能连接进行划分，并且这些细分中的活动对预期疼痛缓解和预期金钱奖励的值进行差异编码。
In addition to their well-established role in signaling rewarding outcomes and reward-predictive cues and in mediating positive reinforcement, there is growing evidence that nucleus accumbens (NAc) neurons also signal aversive events and cues that predict them. Here we use diffusion tractography to subdivide the right NAc into lateral-rostral (putative core, pcore) and medial-caudal (putative shell, pshell) subdivisions in humans. The two subregions exhibited differential structural connectivity, based on probabilistic tractography, to prefrontal cortical and subcortical limbic regions. We also demonstrate unique roles for each of the two subdivisions for monetary reward and thermal pain perception tasks: pshell signaling impending pain and value predictions for monetary gambles and pcore activating with anticipation of cessation of thermal pain (signaling reward value of analgesia). We examined functional connectivity for resting state, monetary reward, and thermal pain tasks, and for all three conditions observed that pcore and pshell of right NAc exhibit distinct patterns of synchrony (functional connectivity) to prefrontal cortical and subcortical limbic targets within the right hemisphere. To validate the NAc segregation, we mirrored the coordinates of right NAc pcore and pshell onto the left hemisphere and examined structural and resting state connectivity in the left hemisphere. This latter analysis closely replicated target-specific connections we obtained for the right hemisphere. Overall, we demonstrate that the human NAc can be parceled based on structural and functional connectivity, and that activity in these subdivisions differentially encodes values for expected pain relief and for expected monetary reward.