Mesothelial cells in tissue repair and fibrosis.
Mesothelial cells in tissue repair and fibrosis.
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DOI：
10.3389/fphar.2015.00113
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发表时间：
2015
影响因子：
5.6
通讯作者：
Prêle CM
中科院分区：
文献类型：
--
作者：
Mutsaers SE;Birnie K;Lansley S;Herrick SE;Lim CB;Prêle CM
间皮细胞是维持浆膜完整性和稳态的基础，并在损伤后的正常浆膜修复中发挥关键作用。然而，当正常修复机制崩溃时，间皮细胞承担促纤维化作用，分泌炎性和促纤维化介质，分化并迁移到损伤组织中，在那里它们促进纤维形成。新的分子和细胞跟踪技术的发展使得有可能检查受损组织中纤维化细胞的起源，并阐明它们在炎症和纤维化中的作用。除了分泌促炎介质并促进凝血和纤维蛋白溶解之外，间皮细胞还经历间皮-间充质转化，这是一种类似于上皮-间充质转化的过程，并成为纤维化细胞。纤维化间皮细胞现在已经在以前没有被认为存在的组织中被鉴定，例如在纤维化肺的实质内。这些发现显示了间皮细胞在纤维发生中的直接作用，以及预防或逆转纤维化过程的开放治疗策略。
Mesothelial cells are fundamental to the maintenance of serosal integrity and homeostasis and play a critical role in normal serosal repair following injury. However, when normal repair mechanisms breakdown, mesothelial cells take on a profibrotic role, secreting inflammatory, and profibrotic mediators, differentiating and migrating into the injured tissues where they contribute to fibrogenesis. The development of new molecular and cell tracking techniques has made it possible to examine the origin of fibrotic cells within damaged tissues and to elucidate the roles they play in inflammation and fibrosis. In addition to secreting proinflammatory mediators and contributing to both coagulation and fibrinolysis, mesothelial cells undergo mesothelial-to-mesenchymal transition, a process analogous to epithelial-to-mesenchymal transition, and become fibrogenic cells. Fibrogenic mesothelial cells have now been identified in tissues where they have not previously been thought to occur, such as within the parenchyma of the fibrotic lung. These findings show a direct role for mesothelial cells in fibrogenesis and open therapeutic strategies to prevent or reverse the fibrotic process.