The role of inflammatory chemokines in lymphoid neoorganogenesis in breast cancer
The role of inflammatory chemokines in lymphoid neoorganogenesis in breast cancer
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DOI：
10.1016/j.biopha.2013.03.017
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发表时间：
2013-06-01
影响因子：
7.5
通讯作者：
Kzyrgalin, S. R.
中科院分区：
文献类型：
--
作者：
Gantsev, S. K.;Umezawa, K.;Kzyrgalin, S. R.
对乳腺癌新形成淋巴结中炎性趋化因子及其受体的表达谱进行了分析。分析发现，CCL16、XCR1、CYFIP2、TNFSF14基因在三级淋巴器官中的表达增加，趋化因子配体CXCL5和CXCL12的表达减少。所获得的结果使我们认为，在自身免疫性疾病和某些感染中，诱导淋巴结新生的过程（在其关键机制上）与淋巴组织新生的过程是相同的，但可能有不同的触发因素。(C) 2013 Elsevier Masson SAS。版权所有。
The expression profiling analysis of inflammatory chemokines and their receptors in newly formed lymph nodes in breast cancer was carried out. The analysis revealed the increase in expression of the genes CCL16, XCR1, CYFIP2, TNFSF14 and the reduction in expression of chemokine ligands CXCL5 and CXCL12 in tertiary lymphoid organs. The obtained results allow us to suggest that the process of induction of lymph nodes neogenesis is identical (in its key mechanisms) to the process of lymphoid tissue neogenesis in autoimmune diseases and in some infections, but may have different triggers. (C) 2013 Elsevier Masson SAS. All rights reserved.