Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution
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DOI：
10.1038/ng2104
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发表时间：
2007-09-01
期刊：
影响因子：
30.8
通讯作者：
Awray, Gregory
中科院分区：
文献类型：
--
作者：
Haygood, Ralph;Fedrigo, Olivier;Awray, Gregory
尽管人类和黑猩猩在行为、认知和饮食方面存在明显差异，但对人类或黑猩猩中蛋白质编码序列进行的正选择证据调查仅标记了少数已知在神经或营养过程中起作用的基因（1-5）（6-8）。这可能是大多数这样的差异是由于基因调控的变化，而不是蛋白质结构（9）。在这里，我们提出了第一次调查的启动子（5 '侧翼）区域，这是丰富的顺式调控序列，在人类中的正选择的证据。我们的研究结果表明，正选择的目标是调节许多已知参与神经发育和功能的基因，无论是在大脑和神经系统的其他地方，以及营养，特别是葡萄糖代谢。
Surveys of protein- coding sequences for evidence of positive selection in humans or chimpanzees have flagged only a few genes known to function in neural or nutritional processes(1-5), despite pronounced differences between humans and chimpanzees in behavior, cognition and diet(6-8). It may be that most such differences are due to changes in gene regulation rather than protein structure(9). Here, we present the first survey of promoter ( 5'- flanking) regions, which are rich in cis-regulatory sequences, for evidence of positive selection in humans. Our results indicate that positive selection has targeted the regulation of many genes known to be involved in neural development and function, both in the brain and elsewhere in the nervous system, and in nutrition, particularly in glucose metabolism.