The impact of immunological parameters on the development of phantom pain after major amputation.
The impact of immunological parameters on the development of phantom pain after major amputation.
复制标题
免疫学参数对大截肢后幻痛发生的影响。
DOI：
10.1016/j.ejvs.2005.02.050
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
W. Lang
中科院分区：
文献类型：
--
作者：
C. Stremmel;C. Horn;S. Eder;A. Dimmler;W. Lang
目的探讨局部和全身炎症标志物与幻肢痛的关系。方法收集39例接受大截肢神经活检的患者的血清和临床资料。结果12个月后，78%的存活患者出现幻肢疼痛，症状通常在术后14天内开始出现。神经活检内巨噬细胞浸润的严重程度与幻觉疼痛的开始呈负相关(P=0.026)。而血清肿瘤坏死因子-α浓度与死亡率呈正相关(P=0.021)。结论截肢前存在的免疫状态和局部免疫环境影响幻觉痛的发生。
OBJECTIVESTo investigate the relationship between local and systemic inflammatory markers and phantom limb pain.METHODSIn 39 consecutive patients undergoing major amputations nerve biopsies, serum and clinical data was collected. Patients were followed up for 12 months to report on the incidence and severity of phantom limb pain.RESULTSAfter 12 months, 78% of the surviving patients had phantom pain, the symptom usually commencing within 14 days of operation. The severity of macrophage infiltration within the nerve biopsy was negatively correlated to the inception of phantom pain (P=0.026). While serum TNF-alpha concentration was positively correlated to mortality (P=0.021).CONCLUSIONSThe immune status existing before the amputation and the local immunological milieu influence the onset of phantom pain.
影响因子：
158.5
作者：
MICHIE, HR;MANOGUE, KR;WILMORE, DW
通讯作者：
WILMORE, DW
影响因子：
7.4
作者：
H. Junger;L. Sorkin
通讯作者：
H. Junger;L. Sorkin
影响因子：
4.3
作者：
Ehde, DM;Czerniecki, JM;Robinson, LR
通讯作者：
Robinson, LR