Von Willebrand factor indicates bacterial translocation, inflammation, and procoagulant imbalance and predicts complications independently of portal hypertension severity
Von Willebrand factor indicates bacterial translocation, inflammation, and procoagulant imbalance and predicts complications independently of portal hypertension severity
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DOI：
10.1111/apt.14522
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发表时间：
2018-04-01
影响因子：
7.6
通讯作者：
Ferlitsch, A.
中科院分区：
文献类型：
--
作者：
Mandorfer, M.;Schwabl, P.;Ferlitsch, A.
背景资料：血浆血管性血友病因子抗原（vWF）升高已被证明表明存在临床意义的门静脉高压症，因此，预测临床事件的发展，在historics.Aim：探讨细菌易位和炎症对vWF的影响，以及vWF和促凝血失衡之间的关联。此外，我们评估了vWF是否预测肝硬化并发症，独立于门静脉高压症的严重程度。方法：我们的研究人群包括225例肝静脉压力梯度（HVPG）>= 10 mm Hg的患者，无活动性细菌感染或肝细胞癌。脂多糖结合蛋白[LBP; =0.201; P=0.021]、炎症[白细胞介素6 [IL-6; =0.426; P
Background: Elevated plasma von Willebrand factor antigen (vWF) has been shown to indicate the presence of clinically significant portal hypertension, and thus, predicts the development of clinical events in patients with cirrhosis.Aim: To investigate the impact of bacterial translocation and inflammation on vWF, as well as the association between vWF and procoagulant imbalance. Moreover, we assessed whether vWF predicts complications of cirrhosis, independent of the severity of portal hypertension.Methods: Our study population comprised 225 patients with hepatic venous pressure gradient (HVPG) >= 10mm Hg without active bacterial infections or hepatocellular carcinoma.Results: vWF correlated with markers of bacterial translocation (lipopolysaccharide-binding protein [LBP; =0.201; P=0.021]), inflammation (interleukin 6 [IL-6; =0.426; P