Perfusion CT in Acute lschemic Stroke: A Qualitative and Quantitative Comparison of Deconvolution and Maximum Slope Approach
Perfusion CT in Acute lschemic Stroke: A Qualitative and Quantitative Comparison of Deconvolution and Maximum Slope Approach
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DOI：
10.3174/ajnr.a2151
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发表时间：
2010-10-01
影响因子：
3.5
通讯作者：
Lell, M. M.
中科院分区：
文献类型：
--
作者：
Abels, B.;Klotz, E.;Lell, M. M.
背景和目的：PCT后处理通常使用MS或DC方法的变体来建模基于体素的时间衰减曲线。有一个正在进行的讨论，这两种方法的各自的优点和局限性，经常在理论推理或模拟数据的基础上。我们进行了定性和定量比较DC和MS通过使用相同的源数据集和预处理parameters.MATERIALS和方法：从PCT数据的50例急性缺血性中风，彩色地图的CBF，CBV，和各种时间参数进行了计算与软件实现DC和MS算法。对彩色图进行定性分类。在非缺血性GM和WM、疑似半暗带和疑似梗死核心中进行基于感兴趣区域的定量测量。结果：DC和MS的CBF和CBV彩色图像质量均较高。在非缺血区域，DC和MS计算的定量CBF和CBV值在相同范围内。在疑似半影区，平均CBFDC低于CBFMS。在疑似梗死核心区域，平均CBVDC与CBFMS相似。使用适应组织的风险/nonviable-tissue阈值，我们发现了良好的相关性DC和MS病变sizes.CONCLUSIONS：DC和MS产生了可比的定性和定量结果。当使用适应阈值时，DC和MS指示的病变大小显示出极好的一致性。在所有情况下，都会做出相同的治疗决定。
BACKGROUND AND PURPOSE: PCT postprocessing commonly uses either the MS or a variant of the DC approach for modeling of voxel-based time-attenuation curves. There is an ongoing discussion about the respective merits and limitations of both methods, frequently on the basis of theoretic reasoning or simulated data. We performed a qualitative and quantitative comparison of DC and MS by using identical source datasets and preprocessing parameters.MATERIALS AND METHODS: From the PCT data of 50 patients with acute ischemic stroke, color maps of CBF, CBV, and various temporal parameters were calculated with software implementing both DC and MS algorithms. Color maps were qualitatively categorized. Quantitative region-of-interest based measurements were made in nonischemic GM and WM, suspected penumbra, and suspected infarction core. Qualitative results, quantitative results, and PCT lesion sizes from DC and MS were statistically compared.RESULTS: CBF and CBV color maps based on DC and MS were of comparably high quality. Quantitative CBF and CBV values calculated by DC and MS were within the same range in nonischemic regions. In suspected penumbra regions, average CBFDC was lower than CBFMS. In suspected infarction core regions, average CBVDC was similar to CBFMS. Using adapted tissue-at-risk/nonviable-tissue thresholds, we found excellent correlation of DC and MS lesion sizes.CONCLUSIONS: DC and MS yielded comparable qualitative and quantitative results. Lesion sizes indicated by DC and MS showed excellent agreement when using adapted thresholds. In all cases, the same therapy decision would have been made.