Longitudinal Associations of Phthalate Exposures During Childhood and Body Size Measurements in Young Girls.
Longitudinal Associations of Phthalate Exposures During Childhood and Body Size Measurements in Young Girls.
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DOI：
10.1097/ede.0000000000000489
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Breast Cancer and Environment Research Program
中科院分区：
文献类型：
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作者：
Deierlein AL;Wolff MS;Pajak A;Pinney SM;Windham GC;Galvez MP;Silva MJ;Calafat AM;Kushi LH;Biro FM;Teitelbaum SL;Breast Cancer and Environment Research Program
邻苯二甲酸盐是一种环境化学物质，可能在肥胖的发展中发挥作用。很少有研究调查了出生后邻苯二甲酸盐暴露与儿童随后的人体测量之间的纵向联系。作为乳腺癌和环境研究项目的一部分，我们在美国的三个地点收集了数据。2004-2007年共有1 239名6-8岁女童入学。我们将基线邻苯二甲酸盐暴露分类，通过肌酐校正的低分子量邻苯二甲酸盐代谢物尿浓度评估为低，<78；中,78 - < 194;而高，肌酸酐≥194 μg/g，高分子量邻苯二甲酸酯为低，<111；中,111 - 278;高，肌酐≥278 μg/g。人体测量数据收集至2012年（n=1,017）。线性混合效应回归估计了基线低分子量和高分子量邻苯二甲酸盐浓度与7至13岁女孩体重指数（BMI）、身高和腰围的变化之间的关系。低分子量邻苯二甲酸酯与体重指数和腰围的增加呈正相关。低分子量邻苯二甲酸盐浓度高与低浓度的女孩之间的BMI和腰围的预测差异分别从0.56 （95%CI: - 0.02, 1.1）增加到1.2 (95%CI: 0.28, 2.1) kg/m2，从1.5 （95%CI: - 0.38, 3.3）增加到3.9 (95%CI: 1.3, 6.5) cm。高分子量邻苯二甲酸酯与身高呈负相关，但仅适用于基线体重正常（BMI≤85百分位）的女孩。邻苯二甲酸酯，特别是低分子量邻苯二甲酸酯，与女孩的人体测量结果有微小但可检测的关联。低分子量邻苯二甲酸酯比其他类型的邻苯二甲酸酯表现出更强的相关性。
Phthalates are environmental chemicals that may play a role in the development of obesity. Few studies have investigated longitudinal associations between postnatal phthalate exposures and subsequent anthropometric measurements in children. We collected data as part of The Breast Cancer and Environment Research Program at three US sites. 1,239 girls, ages 6–8 years, were enrolled in 2004–2007. We categorized baseline phthalate exposures, assessed from creatinine-corrected urinary concentrations of low molecular weight phthalate metabolites as low, <78; medium, 78-<194; and high, ≥194 μg/g creatinine and of high molecular weight phthalates as low, <111; medium, 111–278; and high, ≥278 μg/g creatinine. Anthropometric measurements were collected through 2012 (n=1,017). Linear mixed effects regression estimated how baseline low and high molecular weight phthalate concentrations related to changes in girls’ body mass index (BMI), height, and waist circumference at ages 7 through 13 years. Low molecular weight phthalates were positively associated with gains in BMI and waist circumference. Predicted differences in BMI and waist circumference between girls with high versus low concentrations of low molecular weight phthalates increased from 0.56 (95% CI: −0.02, 1.1) to 1.2 (95%CI: 0.28, 2.1) kg/m2 and from 1.5 (95%CI: −0.38, 3.3) to 3.9 (95%CI: 1.3, 6.5) cm, respectively. High molecular weight phthalates were negatively associated with height but only among girls who were normal weight at baseline (BMI ≤85th percentile). Phthalates, specifically low molecular weight phthalates, have small but detectable associations with girls’ anthropometric outcomes. Low molecular weight phthalates, showed stronger associations than other types of phthalates.