The Neuropsychological Syndrome of Agenesis of the Corpus Callosum.
The Neuropsychological Syndrome of Agenesis of the Corpus Callosum.
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DOI：
10.1017/s135561771800111x
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Paul LK
中科院分区：
文献类型：
--
作者：
Brown WS;Paul LK
胼胝体发育（AgCC）涉及胼胝体的全部或部分先天性缺失。因为这种疾病只能通过神经放射学确诊，所以它的研究历史很短，直到最近认知综合征才变得清晰。我们的目的是审查构成核心综合征的AgCC的主要缺陷。核心综合征包括：（1）感觉-运动信息的半球间传递减少;（2）认知处理速度降低;（3）复杂推理和解决新问题的能力不足。这些领域似乎并不反映不同的神经解剖学异常，而是不同的领域的表达减少半球间的沟通，从胼胝体缺席。这些核心缺陷表现在认知、行为和社会功能的各个领域。这些缺陷的影响因发育而异，并可能受到个体因素的调节，如其他神经发育条件，一般智力能力和环境支持的共同发生。
Agenesis of the corpus callosum (AgCC) involves congenital absence of all or part of the corpus callosum. Because the disorder can only be firmly diagnosed via neuroradiology, it has a short research history, and only recently has the cognitive syndrome become clear. Our purpose is to review the primary deficits in AgCC that constitute the core syndrome. The cores syndrome includes: (1) Reduced interhemispheric transfer of sensory-motor information; (2) Reduced cognitive processing speed; (3) Deficits in complex reasoning and novel problem-solving. These domains do not appear to reflect different neuroanatomical abnormalities, but rather different domains of expression of reduced interhemispheric communication from callosal absence. These core deficits are expressed across various domains of cognitive, behavioral, and social functioning. The impact of these deficits varies across development and may be moderated by individual factors such as cooccurrence of other neurodevelopmental conditions, general intellectual capacity, and environmental support.