GOLPH3 links the Golgi, DNA damage, and cancer.
GOLPH3 links the Golgi, DNA damage, and cancer.
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DOI：
10.1158/0008-5472.can-14-3081
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发表时间：
2015-02-15
期刊：
影响因子：
11.2
通讯作者：
Field SJ
中科院分区：
文献类型：
--
作者：
Buschman MD;Rahajeng J;Field SJ
GOLPH 3是第一个在高尔基体分泌运输中起作用的癌基因的例子。GOLPH 3在癌症和高尔基体运输中的作用的发现引发了关于GOLPH 3和高尔基体如何促进癌症的问题。我们最近对GOLPH 3调控的研究揭示了高尔基体对DNA损伤的惊人反应，该反应由DNA-PK和GOLPH 3介导。这些结果为理解细胞对标准癌症治疗剂的反应提供了对DNA损伤反应的新见解。
GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3’s roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer. Our recent investigation of the regulation of GOLPH3 revealed a surprising response by the Golgi upon DNA damage that is mediated by DNA-PK and GOLPH3. These results provide new insight into the DNA damage response with important implications for understanding the cellular response to standard cancer therapeutic agents.