Monte Carlo study of the GTP cap in a five-start helix model of a microtubule.
Monte Carlo study of the GTP cap in a five-start helix model of a microtubule.
复制标题
微管五线螺旋模型中 GTP 帽的蒙特卡罗研究。
DOI：
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发表时间：
1985
影响因子：
11.1
通讯作者：
T. L. Hill
中科院分区：
文献类型：
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作者：
Y. Chen;T. L. Hill
早期对微管末端 GTP 帽单螺旋模型的蒙特卡洛研究在此扩展到更现实的微管末端五头螺旋模型。与早期的工作一样，相变发生在微管末端：末端要么被 GTP 加帽并缓慢生长，要么不加帽并快速缩短，并且这两种状态在稳态下交替（在给定的微管蛋白浓度下）。两相模型的宏观速率常数是从蒙特卡罗结果推导出来的。宏观速率常数导致的性质与 Mitchison 和 Kirschner 的相关实验半定量一致。
Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier work, phase changes occur at the microtubule end: the end is either capped with GTP and growing slowly or uncapped and shortening rapidly, and these two regimes alternate (at a given tubulin concentration) at steady state. Macroscopic rate constants for the two-phase model are deduced from the Monte Carlo results. The macroscopic rate constants lead to properties that are in semiquantitative agreement with related experiments of Mitchison and Kirschner.