Parkinson's disease between internal medicine and neurology.
Parkinson's disease between internal medicine and neurology.
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DOI：
10.1007/s00702-015-1443-z
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Reichmann H
中科院分区：
文献类型：
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作者：
Csoti I;Jost WH;Reichmann H
一般的医疗问题和并发症对帕金森病各个阶段的生活质量有重大影响。为了引入有效的治疗方法，必须对各种临床症状进行综合分析。我们必须区分（1）与帕金森病无关的疾病，和（2）帕金森病直接或间接后果的疾病。医疗合并症可能会导致额外的限制，体力和应对策略，并可能因此限制了疗效的物理治疗，这是必不可少的治疗运动功能减退僵硬症状。在选择适当的药物治疗可能出现的任何其他医学症状时，必须考虑其局限性，禁忌症和与多巴胺能物质的相互作用。一般医学症状和器官表现也可能作为与帕金森病相关的自主神经功能障碍的直接后果而出现。随着疾病的进展，可能会出现其他非帕金森症状。此外，帕金森药物的副作用可能需要其他医学专家的参与。在这篇综述中，我们将讨论帕金森病的各种一般医学方面。
General medical problems and complications have a major impact on the quality of life in all stages of Parkinson’s disease. To introduce an effective treatment, a comprehensive analysis of the various clinical symptoms must be undertaken. One must distinguish between (1) diseases which arise independently of Parkinson’s disease, and (2) diseases which are a direct or indirect consequence of Parkinson’s disease. Medical comorbidity may induce additional limitations to physical strength and coping strategies, and may thus restrict the efficacy of the physical therapy which is essential for treating hypokinetic-rigid symptoms. In selecting the appropriate medication for the treatment of any additional medical symptoms, which may arise, its limitations, contraindications and interactions with dopaminergic substances have to be taken into consideration. General medical symptoms and organ manifestations may also arise as a direct consequence of the autonomic dysfunction associated with Parkinson’s disease. As the disease progresses, additional non-parkinsonian symptoms can be of concern. Furthermore, the side effects of Parkinson medications may necessitate the involvement of other medical specialists. In this review, we will discuss the various general medical aspects of Parkinson’s disease.