Metabolic alterations in corpus callosum may compromise brain functional connectivity in MTBI patients: An 1H-MRS study
Metabolic alterations in corpus callosum may compromise brain functional connectivity in MTBI patients: An 1H-MRS study
复制标题
DOI：
10.1016/j.neulet.2011.11.013
复制
发表时间：
2012-02-10
影响因子：
2.5
通讯作者：
Slobounov, Semyon
中科院分区：
文献类型：
--
作者：
Johnson, Brian;Zhang, Kai;Slobounov, Semyon
在轻度创伤性脑损伤（MTBI）的体征和症状得到临床解决后，仍然不清楚是否存在结构或功能性脑网络的残留异常。我们之前已经记录了“无症状”脑震荡个体在亚急性损伤阶段的半球间功能连接中断。15名正常志愿者（NV）和15名亚急性MTBI受试者在临床症状消退和医学清除后24小时内进行第一阶段有氧运动测试。在这项MRS研究中，我们报告：(a)与NVs相比，MTBI受试者损伤后不久，胼胝体的膝部和脾部的NAA/Cho和NAA/Cr比值显著（p < 0.05）降低；(b)正常志愿者脾脏的代谢比率NAA/Cho与海马间功能连接的大小显著相关，但在MTBI中没有。这一新发现支持了我们的假设，即MTBI受试者的半球间脑网络功能破坏是由于胼胝体代谢完整性受损造成的，尽管临床明显恢复到基线，但这种情况仍然存在。2011爱思唯尔爱尔兰有限公司版权所有。
After clinical resolution of signs and symptoms of mild traumatic brain injury (MTBI) it is still not clear if there are residual abnormalities of structural or functional brain networks. We have previously documented disrupted interhemispheric functional connectivity in 'asymptomatic' concussed individuals during the sub-acute phase of injury. Testing of 15 normal volunteers (NV) and 15 subacute MTBI subjects was performed within 24 h of clinical symptoms resolution and medical clearance for the first stage of aerobic activity. In this MRS study we report: (a) both in the genu and splenium of the corpus callosum NAA/Cho and NAA/Cr ratios were significantly (p < 0.05) lower in MTBI subjects shortly after the injury compared to NVs, and (b) the metabolic ratio NAA/Cho in the splenium significantly correlated with the magnitude of inter-hippocampal functional connectivity in normal volunteers, but not in MTBI. This novel finding supports our hypothesis that the functional disruption of interhemispheric brain networks in MTBI subjects results from compromised metabolic integrity of the corpus callosum and that this persists despite apparent clinical return to baseline. (C) 2011 Elsevier Ireland Ltd. All rights reserved.