Rapid T2 mapping of mouse heart using the carr-purcell-meiboom-gill sequence and compressed sensing reconstruction.
Rapid T2 mapping of mouse heart using the carr-purcell-meiboom-gill sequence and compressed sensing reconstruction.
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DOI：
10.1002/jmri.25175
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Chen Y;Li W;Jiang K;Wang CY;Yu X
开发和验证一种小鼠心脏快速体内T2标测技术的初步验证。MRI实验在7T动物扫描仪上进行。对标准的Carr-Purcell-Meiom-Gill(CPMG)序列进行了修改，以最大限度地减少刺激回声的影响，以实现准确的T2定量。利用压缩传感方法进一步加快了收购的速度。首先通过体模实验和数值模拟验证了该方法的准确性。在一项锰增强磁共振研究中，对7只小鼠进行了体内T2测量。在体模研究中，用改进的CPMG序列得到的T2值与标准的自旋回波方法非常一致(P&gT；0.05)。数值模拟进一步证明，应用压缩传感方法，可以在每个切片1min的高时间分辨率下实现空间分辨率为2.3 mm的快速T2量化。用所提出的技术，在7T时，小鼠心脏的平均T2值为25毫秒，并且在注入锰后这个数字显著降低(P<；0.001)。开发并评估了一种快速T2映射技术，该技术允许以每片一分钟的时间分辨率对小鼠心脏进行准确的T2量化。
To develop and prove preliminary validation of a fast in vivo T2 mapping technique for mouse heart. MRI experiments were performed on a 7T animal scanner. The standard Carr-Purcell-Meiboom-Gill (CPMG) sequence was modified to minimize the effect of stimulated echoes for accurate T2 quantification. The acquisition was further accelerated with the compressed sensing approach. The accuracy of the proposed method was first validated with both phantom experiments and numerical simulations. In vivo T2 measurement was performed on seven mice in a manganese-enhanced MRI study. In phantom studies, T2 values obtained with the modified CPMG sequence are in good agreement with the standard spin-echo method (P > 0.05). Numerical simulations further demonstrated that with the application of the compressed sensing approach, fast T2 quantification with a spatial resolution of 2.3 mm can be achieved at a high temporal resolution of one minute per slice. With the proposed technique, an average T2 value of 25 msec was observed for mouse heart at 7T and this number decreased significantly after manganese infusion (P < 0.001). A rapid T2 mapping technique was developed and assessed, which allows accurate T2 quantification of mouse heart at a temporal resolution of one minute per slice.