Reliable Quantitative SERS Analysis Facilitated by Core-Shell Nanoparticles with Embedded Internal Standards
Reliable Quantitative SERS Analysis Facilitated by Core-Shell Nanoparticles with Embedded Internal Standards
复制标题
嵌入内标的核壳纳米粒子促进可靠的定量 SERS 分析
DOI：
10.1002/anie.201502171
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发表时间：
2015-06-15
影响因子：
16.6
通讯作者：
Ren, Bin
中科院分区：
文献类型：
--
作者：
Shen, Wei;Lin, Xuan;Ren, Bin
定量分析是表面增强拉曼散射（Sers）技术中的一个重大挑战。通过合理设计核-分子-壳结构纳米粒子，分子层由骨架分子构成，探针分子作为拉曼内标，可用于定量Sers分析。嵌入式拉曼探针的信号提供了有效的反馈，以校正样品和测量条件的波动。同时，具有不同亲和力的目标分子可以吸附到壳上。在一个大的浓度范围内的目标分子的定量分析已被证明与相对的Sers强度与表面覆盖度的线性响应，这还没有通过常规的Sers方法实现。
Quantitative analysis is a great challenge in surface-enhanced Raman scattering (SERS). Core-molecule-shell nanoparticles with two components in the molecular layer, a framework molecule to form the shell, and a probe molecule as a Raman internal standard, were rationally designed for quantitative SERS analysis. The signal of the embedded Raman probe provides effective feedback to correct the fluctuation of samples and measuring conditions. Meanwhile, target molecules with different affinities can be adsorbed onto the shell. The quantitative analysis of target molecules over a large concentration range has been demonstrated with a linear response of the relative SERS intensity versus the surface coverage, which has not been achieved by conventional SERS methods.