The inflammatory role of platelets in cystic fibrosis
The inflammatory role of platelets in cystic fibrosis
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DOI：
10.1164/rccm.200508-1243pp
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发表时间：
2006-03-01
影响因子：
24.7
通讯作者：
Michelson, AD
中科院分区：
文献类型：
--
作者：
O'Sullivan, BP;Michelson, AD
血小板是炎症级联反应的一个重要组成部分，尽管通常被低估。已知血小板在动脉粥样硬化、中风和哮喘中促进炎症。它们产生大量促炎脂质介质和细胞因子，并在将白细胞募集到炎症组织中中起重要作用。我们回顾了血小板在炎症中的作用，它们如何帮助哮喘患者招募白细胞进入肺组织，以及它们在囊性纤维化（CF）中功能障碍的证据。CF中的血小板功能障碍可能导致肺部炎症和组织破坏。我们假设血小板活化在CF肺病中很重要，并提出可能有助于阐明活化血小板在CF中作用的研究途径。
Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocytes into inflamed tissue. We review the role of platelets in inflammation, how they assist in the recruitment of leukocytes into lung tissue in asthma, and evidence of their dysfunction in cystic fibrosis (CF). Platelet dysfunction in CF could contribute to pulmonary inflammation and tissue destruction. We hypothesize that platelet activation is important in CF lung disease and suggest research avenues that might help elucidate the role of activated platelets in CF.