Catalytic galactose oxidase models: Biomimetic Cu(II)-phenoxyl-radical reactivity
Catalytic galactose oxidase models: Biomimetic Cu(II)-phenoxyl-radical reactivity
复制标题
DOI：
10.1126/science.279.5350.537
复制
发表时间：
1998-01-23
期刊：
影响因子：
56.9
通讯作者：
Stack, TDP
中科院分区：
文献类型：
--
作者：
Wang, YD;DuBois, JL;Stack, TDP
提出了单核铜酶半乳糖氧化酶的仿生功能模型，该模型在温和条件下用O-2催化氧化苄醇和烯丙醇为醛，模型与天然体系之间的机理保真度是显著的。适度的结构模仿证明足以转移一个不寻常的配体为基础的自由基机制，以前前所未有的蛋白质基质外，一个简单的化学系统。
Biomimetic functional models of the mononuclear copper enzyme galactose oxidase are presented that catalytically oxidize benzylic and allylic alcohols to aldehydes with O-2 under mild conditions, The mechanistic fidelity between the models and the natural system is pronounced. Modest structural mimicry proves sufficient to transfer an unusual ligand-based radical mechanism, previously unprecedented outside the protein matrix, to a simple chemical system.