Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma.
Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma.
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DOI：
10.3390/bios11020055
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发表时间：
2021-02-20
期刊：
影响因子：
--
通讯作者：
Kang M
中科院分区：
文献类型：
--
作者：
Barani M;Mukhtar M;Rahdar A;Sargazi S;Pandey S;Kang M
骨肉瘤（OSA）是一种起源于形成骨骼的细胞的骨癌。OSA是一种罕见的间充质骨肿瘤，来源于间充质干细胞。基因组紊乱、染色体修饰、肿瘤抑制基因的失调和DNA修复缺陷是导致OSA发展的最主要因素。尽管在OSA的诊断和治疗方面取得了重大进展，但在过去的二十年中，患者的总体生存率并未改善。最近，现代纳米技术的进步促进了OSA管理的发展，并提供了几个优势，以克服传统疗法的缺点。该技术允许结合许多功能分子的纳米级装置的实际设计，包括肿瘤特异性配体，抗体，抗癌药物和成像探针。由于它们的小尺寸，理想的药物包封效率和良好的生物利用度，功能化纳米材料已被广泛应用于对抗OSA进展。这篇综述援引了工程纳米材料在OSA诊断和治疗中的可能效用，激励研究人员寻求新的策略来应对与之相关的挑战。
Osteosarcoma (OSA) is a type of bone cancer that begins in the cells that form bones.OSA is a rare mesenchymal bone neoplasm derived from mesenchymal stem cells. Genome disorganization, chromosomal modifications, deregulation of tumor suppressor genes, and DNA repair defects are the factors most responsible for OSA development. Despite significant advances in the diagnosing and treatment of OSA, patients’ overall survival has not improved within the last twenty years. Lately, advances in modern nanotechnology have spurred development in OSA management and offered several advantages to overcome the drawbacks of conventional therapies. This technology has allowed the practical design of nanoscale devices combined with numerous functional molecules, including tumor-specific ligands, antibodies, anti-cancer drugs, and imaging probes. Thanks to their small sizes, desirable drug encapsulation efficiency, and good bioavailability, functionalized nanomaterials have found wide-spread applications for combating OSA progression. This review invokes the possible utility of engineered nanomaterials in OSA diagnosis and treatment, motivating the researchers to seek new strategies for tackling the challenges associated with it.
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基于白蛋白的治疗诊断纳米药物的光触发保留和级联治疗可减轻肿瘤适应性治疗耐受性
影响因子：
19
作者：
Chen, Jing;Liu, Lu;Liang, Xing-Jie
通讯作者：
Liang, Xing-Jie
影响因子：
3.8
作者：
Chen B;Yang JZ;Wang LF;Zhang YJ;Lin XJ
通讯作者：
Lin XJ
影响因子：
5.8
作者：
Chen, Zhizhong;Yu, Hongchang;Wang, Yangyun
通讯作者：
Wang, Yangyun
影响因子：
10.8
作者：
Chi, Yingying;Yin, Xuelei;Wu, Zimei
通讯作者：
Wu, Zimei
DOI：
10.3390/nano10091696
发表时间：
2020-08-28
期刊：
Nanomaterials (Basel, Switzerland)
影响因子：
--
作者：
Barani M;Sabir F;Rahdar A;Arshad R;Kyzas GZ
通讯作者：
Kyzas GZ