DELLAs Modulate Jasmonate Signaling via Competitive Binding to JAZs
DELLAs Modulate Jasmonate Signaling via Competitive Binding to JAZs
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DOI：
10.1016/j.devcel.2010.10.024
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发表时间：
2010-12-14
影响因子：
11.8
通讯作者：
Yu, Hao
中科院分区：
文献类型：
--
作者：
Hou, Xingliang;Lee, Li Yen Candy;Yu, Hao
赤霉素（GAs）调节茉莉酸（JA）信号，而JA信号在植物的胁迫反应和发育中是必不可少的。然而，这种植物激素相互作用的分子细节在很大程度上仍然未知。在这里，我们表明，JA ZIM结构域1（JAZ1）蛋白，JA信号传导的关键阻遏物，在体内与DELLA蛋白，GA途径的阻遏物相互作用。DELLA阻止JAZ1与JA应答的关键转录激活因子MYC2的抑制性相互作用，从而增强MYC2调节其靶基因的能力。相反，GA触发DELLA的降解，这使得JAZ1结合MYC2并抑制MYC2依赖性JA信号输出。因此，我们的研究结果揭示了一种手段，其中GAs抑制细胞的能力，以响应JA。由于DELLA作为中央调节器，介导各种植物激素的串扰，我们的模型还提出了一个候选机制，通过该机制，JA信号可以通过其他信号通路通过DELLA进行微调。
Gibberellins (GAs) modulate jasmonate (JA) signaling, which is essential for stress response and development in plants. However, the molecular details of such phytohormone interaction remain largely unknown. Here, we show that the JA ZIM-domain 1 (JAZ1) protein, a key repressor of JA signaling, interacts in vivo with DELLA proteins, repressors of the GA pathway. DELLAs prevent inhibitory JAZ1 interaction with a key transcriptional activator of JA responses, MYC2, and, thus, enhance the ability of MYC2 to regulate its target genes. Conversely, GA triggers degradation of DELLAs, which allows JAZ1 to bind MYC2 and suppress MYC2-dependent JA-signaling outputs. Therefore, our results reveal one means by which GAs suppress cellular competence to respond to JA. Because DELLAs serve as central regulators that mediate the crosstalk of various phytohormones, our model also suggests a candidate mechanism by which JA signaling may be fine-tuned by other signaling pathways through DELLAs.