Deaths among people with hepatitis C in New York City, 2000-2011.
Deaths among people with hepatitis C in New York City, 2000-2011.
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DOI：
10.1093/cid/ciu075
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发表时间：
2014-04
期刊：
影响因子：
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通讯作者：
J. Pinchoff;A. Drobnik;K. Bornschlegel;S. Braunstein;Christine Chan;J. Varma;J. Fuld
中科院分区：
文献类型：
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作者：
J. Pinchoff;A. Drobnik;K. Bornschlegel;S. Braunstein;Christine Chan;J. Varma;J. Fuld
背景技术丙型肝炎病毒（HCV）感染会增加因肝脏和非肝脏相关疾病死亡的风险。与人类免疫缺陷病毒（HIV）合并感染会进一步增加这种风险。方法 对纽约市健康和心理卫生局 (DOHMH) 维护的监测数据（2000-2010 年）和死亡率数据（2000-2011 年）进行确定性交叉匹配。对感染 HCV 的成年死者的相关因素和死亡原因进行了分析。结果 2000年至2011年间，13 307名HCV单一感染成年人死亡，5475名HCV/HIV合并感染成年人死亡。与未感染 HCV 的人相比，HCV 单一感染的死者更有可能死于肝癌（比值比 [OR] = 9.2）、药物相关原因（OR = 4.3）和肝硬化（OR = 3.7）。与未感染 HCV/HIV 的人相比，同时感染 HCV/HIV 的死者更有可能死于肝癌 (OR = 2.2) 和药物相关原因 (OR = 3.1)。在合并感染的死者中，53.6%的死亡归因于艾滋病毒/艾滋病，94%的死亡发生在过早（65岁之前）。在死亡的 HCV 感染者中，一半以上在向 DOHMH 报告 HCV 后 3 年内死亡。结论 感染 HCV 的成年人死亡和过早死亡的风险增加，特别是因与 HCV 相关的疾病，如 HIV/艾滋病或吸毒。 HCV 报告与死亡之间的短暂间隔表明需要早期检测和改进治疗。
BACKGROUND Infection with hepatitis C virus (HCV) increases the risk of death from liver and nonliver-related diseases. Coinfection with human immunodeficiency virus (HIV) further increases this risk. METHODS Surveillance data (2000-2010) and mortality data (2000-2011) maintained by the New York City Department of Health and Mental Hygiene (DOHMH) were deterministically cross-matched. Factors associated with and causes of death among HCV-infected adult decedents were analyzed. RESULTS Between 2000 and 2011, 13 307 HCV-monoinfected adults died, and 5475 adults coinfected with HCV/HIV died. Decedents with HCV monoinfection were more likely to have died of liver cancer (odds ratio [OR] = 9.2), drug-related causes (OR = 4.3), and cirrhosis (OR = 3.7), compared with persons with neither infection. HCV/HIV-coinfected decedents were more likely to have died of liver cancer (OR = 2.2) and drug-related causes (OR = 3.1), compared with persons with neither infection. Among coinfected decedents, 53.6% of deaths were attributed to HIV/AIDS, and 94% of deaths occurred prematurely (before age 65). Among persons with HCV who died, more than half died within 3 years of an HCV report to DOHMH. CONCLUSIONS HCV-infected adults were at increased risk of dying and of dying prematurely, particularly from conditions associated with HCV, such as HIV/AIDS or drug use. The short interval between HCV report and death suggests a need for earlier testing and improved treatment.