TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men.
TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men.
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人HNF4G基因rs2941484的TT基因型与中国汉族男性高尿酸血症相关
DOI：
10.18632/oncotarget.15851
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发表时间：
2017-04-18
期刊：
影响因子：
--
通讯作者：
Ma YT
中科院分区：
文献类型：
--
作者：
Chen BD;Chen XC;Pan S;Yang YN;He CH;Liu F;Ma X;Gai MT;Ma YT
本研究的目的是探讨中国汉族人肝细胞核因子4 γ（HNF 4G）基因与高尿酸血症的关系。共纳入414例高尿酸血症患者和406例性别和年龄匹配的正常尿酸血症对照。4个单核苷酸多态性基因型作为人类HNF 4G基因的遗传标记（rs2977939、rs1805098、rs2941484、rs4735692）。分析了两个独立组的数据：男性和女性。rs2941484基因型在高尿酸血症患者中的分布频率与正常尿酸血症男性对照组相比有显著性差异（P = 0.038）。同时，rs2941484隐性模式中，TT基因型和CC+CT基因型在高尿酸血症组和正常尿酸血症组中的分布频率也有显著性差异（P = 0.011）。另外3个SNPs在男性和女性中的基因型、等位基因和分布频率在高尿酸血症组和正常尿酸血症组之间均无差异。在男性中，校正BMI、SBP、DBP、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇和肌酐后，rs2941484 TT基因型男性患高尿酸血症的概率显著高于CT和CC基因型男性（OR = 2.170，P < 0.001）。因此，HNF 4G基因rs2941484位点TT基因型可能是中国汉族男性高尿酸血症的一个性别特异性遗传标记。
The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma (HNF4G) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polymorphisms were genotyped as genetic markers for the human HNF4G gene (rs2977939, rs1805098, rs2941484, rs4735692). Data were analyzed for two separate groups: men and women. For rs2941484, the genotype distribution frequency in hyperuricemic subjects and was significantly different from that in normouricemic controls in men (P = 0.038). Meanwhile, in recessive model of rs2941484, the distribution frequency of TT genotype and CC+CT genotypes also differed significantly between the hyperuricemia men and normouricemic men (P = 0.011). For the other 3 SNPs in both men and women, there was no difference in the genotype and allele and distribution frequency between the hyperuricemia patients and normouricemic controls. In men, after adjustments for BMI, SBP, DBP, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol and creatinine, the men with the TT genotype of rs2941484 were found to have significantly higher probability of suffering from hyperuricemia than the ones with CT and CC genotypes (OR = 2.170, P < 0.001). Therefore, TT genotype of rs2941484 in the human HNF4G gene might be a gender-specific genetic marker for hyperuricemia in Chinese Han men.