Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response.
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response.
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TH2 介导的免疫反应是在感染多细胞寄生虫时诱导的，并且可以由多种过敏原触发。参与 TH2 反应激活的诱导机制和抗原呈递细胞仍不清楚，并且寄生虫和过敏原激活的先天免疫传感途径在很大程度上未知。体内蛋白酶过敏原诱导 TH2 反应需要嗜碱性粒细胞。在这里，我们证明嗜碱性粒细胞也起到抗原呈递细胞的作用。我们发现，虽然树突状细胞是可有可无的，但嗜碱性粒细胞的抗原呈递对于过敏原诱导的体外和体内 TH2 反应激活是必要且充分的。因此，嗜碱性粒细胞充当抗原呈递细胞，用于响应蛋白酶过敏原而分化为TH2。
TH2 mediated immune responses are induced upon infection with multicellular parasites and can be triggered by a variety of allergens. Mechanisms of induction and the antigen-presenting cells involved in activation of TH2 responses remain poorly defined and the innate immune sensing pathways activated by parasites and allergens are largely unknown. Basophils are required for the in vivo induction of TH2 responses by protease allergens. Here we show that basophils also function as antigen presenting cells. We show that, while dendritic cells were dispensable, antigen presentation by basophils was necessary and sufficient for allergen-induced activation of TH2 responses in vitro and in vivo. Thus, basophils function as antigen presenting cells for TH2 differentiation in response to protease allergens.
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影响因子：
4.4
作者：
Li, Hanfen;Willingham, Stephen B.;Ting, Jenny P. -Y.;Re, Fabio
通讯作者：
Re, Fabio
DOI：
10.1084/jem.180.4.1367
发表时间：
1994-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chang CH;Fontes JD;Peterlin M;Flavell RA
通讯作者：
Flavell RA
影响因子：
32.4
作者：
Jung, S;Unutmaz, D;Lang, RA
通讯作者：
Lang, RA
影响因子：
4.4
作者：
Lemos, MP;Fan, L;Laufer, TM
通讯作者：
Laufer, TM
影响因子：
30.5
作者：
通讯作者：
--