Oleanane-Type Isomeric Triterpenoids from Barringtonia racemosa
Oleanane-Type Isomeric Triterpenoids from Barringtonia racemosa
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DOI：
10.1021/np8007396
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发表时间：
2009-04-01
影响因子：
5.1
通讯作者：
Rao, J. Madhusudana
中科院分区：
文献类型：
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作者：
Gowri, P. Mangala;Radhakrishnan, S. V. S.;Rao, J. Madhusudana
从总状巴灵通干果的甲醇提取物中分离得到两个新的异构化齐墩果烷类三萜类化合物和三个已知化合物。在波谱方法的基础上，结合一维和二维核磁共振技术以及化学方法，确定了它们的结构为外消旋醇A(1)[22α-乙酰氧基-3β，15α，16α，21 beta-tetrahydroxy-28-(2-methylbutyryl)olean-12-ene]和异克拉克莫索A(2)[21β-乙酰氧基-3β，15α，16α，28-四羟基-22α-(2-甲基丁酰基)油-12-烯]。分离得到的化合物(1-5)对HeLa和P388-D_1癌细胞无抑制作用。
Two new isomeric acylated oleanane-type triterpenoids along with three known compounds were isolated from the MeOH extract of the dried fruits of Barringtonia racemosa. On the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques as well as chemical methods, the structures were characterized as racemosol A (1) [22 alpha-acetoxy-3 beta,15 alpha, 16 alpha,21 beta-tetrahydroxy-28-(2-methylbutyryl)olean-12-ene] and iscracemosol A (2) [21 beta-acetoxy-3 beta,15 alpha, 16 alpha,28-tetrahydroxy-22 alpha-(2-methylbutyryl)olean-12-ene]. The isolated compounds (1-5) were not active against HeLa and P388 D1 carcinoma cell lines.