Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery
Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery
复制标题
DOI：
10.1016/s0168-3659(02)00074-3
复制
发表时间：
2002-06-17
影响因子：
10.8
通讯作者：
Desai, TA
中科院分区：
文献类型：
--
作者：
Ahmed, A;Bonner, C;Desai, TA
近年来，已经设计了多种递送系统来改善药物的口服生物利用度，包括肠溶包衣片剂、胶囊、颗粒和脂质体。微制造技术可能提供一些潜在的优势，传统的药物输送技术。该技术与适当的表面化学相结合，可以允许药物、渗透增强剂和/或促进剂的高度局部化和单向释放。在这项研究中，我们展示了原型的制造包含微器件和表面化学协议，可用于结合凝集素通过抗生物素蛋白-生物素相互作用，这些微机械药物输送车辆。微加工的使用允许定制药物递送载体的尺寸、形状、储库体积和表面特征。体外研究表明，这些凝集素共轭硅微器件的生物粘附增强。该方法可用于通过创建稳健的混合有机/无机递送系统来改善消化活性生物聚合物（例如肽、蛋白质和寡核苷酸）在GI系统中的靶向位点处进入循环的吸收。本文介绍了第一个应用微加工口服给药。(C)2002 Elsevier Science B. V.保留所有权利。
A variety of delivery systems have been devised, in recent years, to improve the oral bioavailability of drugs including enterically coated tablets, capsules, particles, and liposomes. Microfabrication technology may offer some potential advantages over conventional drug delivery technologies. This technology, combined with appropriate surface chemistry, may permit the highly localized and unidirectional release of drugs, permeation enhancers, and/or promoters. In this study, we demonstrate the fabrication of prototype reservoir-containing microdevices and a surface chemistry protocol that can be used to bind lectin via avidin-biotin interactions to these micromachined drug delivery vehicles. The use of microfabrication allows one to tailor the size, shape, reservoir volume, and surface characteristics of the drug delivery vehicle. In vitro studies show enhanced bioadhesion of these lectin conjugated silicon microdevices. This approach may be used to improve the absorption of pharmacologically active biopolymers such as peptides, proteins and oligonucleotides into circulation at targeted sites in the GI system via the creation of a robust hybrid organic/inorganic delivery system. This paper describes one of the first applications of microfabrication to oral drug delivery. (C) 2002 Elsevier Science B.V. All rights reserved.