Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
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DOI：
10.2217/epi-2023-0164
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发表时间：
2023-09
期刊：
影响因子：
3.8
通讯作者：
B. Joyce;Xuefen Chen;Tao Gao;Yinan Zheng;D. Nannini;Lei Liu;B. Henkle;Ravi Kalhan;G. Washko-G.-Was
中科院分区：
文献类型：
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作者：
B. Joyce;Xuefen Chen;Tao Gao;Yinan Zheng;D. Nannini;Lei Liu;B. Henkle;Ravi Kalhan;G. Washko-G.-Was
背景：本研究的目的是确定肺功能是否与表观遗传衰老 (GrimAge) 相关以及 GrimAge 是否可以预测肺气肿。方法：这项前瞻性研究调查了作为基于社区的纵向队列的一部分登记的 1042 名参与者。在研究第 20 年（参与者年龄为 40-45 岁）测量的肺功能与 GrimAge 之间的横断面关联，以及第 25 年与肺气肿的前瞻性关联进行了检查。结果：20 岁时，1 秒用力呼气量 (FEV1) 和 FEV1/用力肺活量 (FVC) 与 GrimAge 呈负相关；对于 Y0-Y10 累积测量值，只有 FEV1/FVC 比值与 Y15 和 Y20 的 GrimAge 相关。第 25 年的肺气肿与第 15 年和第 20 年的 GrimAge 相关。结论：早中期肺功能与 GrimAge 相关； GrimAge 部分介导了肺功能和肺气肿之间的关联。
Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.