Influence of bubble size distribution on the echogenicity of ultrasound contrast agents -: A study of SonoVue™
Influence of bubble size distribution on the echogenicity of ultrasound contrast agents -: A study of SonoVue™
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DOI：
10.1097/00004424-200011000-00003
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发表时间：
2000-11-01
影响因子：
6.7
通讯作者：
Schneider, M
中科院分区：
文献类型：
--
作者：
Gorce, JM;Arditi, M;Schneider, M
理由和目标。研究不同气泡大小类别对SONOVUE（TM）的相对贡献（TM）在基本声学成像模式中的回声。 SONOVUE（TM）是一种对比剂，以前称为BR1，其气泡尺寸分布从约0.7妈妈延伸到10个MUM。确定了Sonovue（TM）声音响应的模型，并为一组实验数据验证。该模型用于模拟标准批量的Sonovue（TM）的声学响应，作为非重叠气泡大小类别的响应之和。首先对标准SONOVUE（TM）气泡尺寸分布进行了验证。当将此分布视为五个尺寸类别具有相等数量的气泡时，发现小于2 MUM的气泡占总数的60％，但仅包含总气体量的5％。模拟结果表明，这些类别的声学贡献明显差异，其中80％的声学功效由气泡直径3至9妈妈提供。该研究还比较了数量，表面和体积的气泡分布与根据声学功效（结论）计算的分布。这项研究表明了为什么气泡体积比气泡计数更好地指标（TM）的功效。在大约2个妈妈的SONOVUE（TM）微泡中发现直径较低，在此大小的气泡在医疗超声频率下的回声性并不明显。
RATIONALE AND OBJECTIVES. TO study the relative contributions of different bubble size classes to SonoVue(TM)'s echogenicity in fundamental acoustic imaging modes. SonoVue(TM) is a contrast agent, previously known as BR1, with a bubble size distribution extending from approximately 0.7 to 10 mum,METHODS. A model for the acoustic response of SonoVue(TM) was determined and validated for a set of experimental data. This model was used to simulate the acoustic response of a standard batch of SonoVue(TM) as the sum of responses of nonoverlapping bubble size classes.RESULTS. The simulation was first validated for a standard SonoVue(TM) bubble size distribution. When this distribution was considered as five size classes with equal numbers of bubbles, it was found that bubbles smaller than 2 mum accounted for 60% of the total number but contained only 5% of the total gas volume. The simulation results indicated marked differences in the acoustic contributions from these classes, with 80% of the acoustic efficacy provided by bubbles 3 to 9 mum in diameter. The study also compared bubble distributions in number, surface, and volume, with the distribution computed in terms of acoustic efficacy,CONCLUSIONS. This study shows why bubble volume is a much better indicator of SonoVue(TM)'s efficacy than is bubble count. A low threshold in diameter was found for SonoVue(TM) microbubbles at approximately 2 mum, under which size bubbles do not contribute appreciably to the echogenicity at medical ultrasound frequencies.